Male fertility depends on intensity of (sperm) metabolism

Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility. https://www.nature.com/articles/nature09767 https://www.sciencedaily.com/releases/2016/03/160317150803.htmhttps://www.sciencedaily.com/releases/2016/03/160317150803.htm However, I suspected that this is not the whole story behind … Read more Male fertility depends on intensity of (sperm) metabolism

Pregnenolone (P5) fully prevents testicular atrophy due to steroid (ab)use or high estrogen

I often get emails from bodybuilders, athletes and others who have used or currently use steroids and want to either protect themselves while using those steroids or want to recover after long-term usage. It is well-known that most performance enhancing steroids, including plain testosterone (T) or DHT, suppress gonadal function through a negative feedback mechanism … Read more Pregnenolone (P5) fully prevents testicular atrophy due to steroid (ab)use or high estrogen

Allopregnanolone as a treatment of Alzheimer Disease (AD)

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that pregnenolone, progesterone and ALLO are all endotoxin antagonists and … Read more Allopregnanolone as a treatment of Alzheimer Disease (AD)

Progesterone may bind and deactivate endotoxin (LPS) directly

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation. http://haidut.me/?p=17 It is well-known that glucocorticoids and mineralocorticoids are protective against endotoxemic shock, possibly due to blocking the hypotensive and inflammatory effects of endotoxin. However, … Read more Progesterone may bind and deactivate endotoxin (LPS) directly

Consciousness is quantum, can be modulated with specific chemicals

Many readers are likely familiar with the theories of Roger Penrose on the topics of consciousness and how it relates to physics and even cosmology. He is perhaps the most vocal proponent of “quantum consciousness” theories, including his own theory known as “orchestrated objective reduction”. The topic of anesthetics and how they work has always … Read more Consciousness is quantum, can be modulated with specific chemicals

Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects mainly through activation of the TLR4 receptor, and pregnenolone … Read more Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

Pregnenolone safe and effective for low-back pain

After failing to find any effective treatments for the many ills that plague veterans, doctors are finally turning to older remedies successfully used back in the first half of the 20th century. Pregnenolone is one such remedy and I have been seeing more and more studies and ongoing trials with it for variety of conditions … Read more Pregnenolone safe and effective for low-back pain