Niacinamide increases aerobic capacity, muscle endurance in humans

There has been a steady increase in human studies with vitamin B3 analogs over the last 3-5 years. Most of that human research is sponsored by the company ChromaDex, which sells a proprietary formulation of nicotinamide riboside (NR), despite its own studies demonstrating that niacinamide / nicotinamide (NAM) is just as effective at raising NAD/NADH … Read more

Vitamin D deficiency impairs muscles by lowering energy production

Perhaps this study below will put some of the arguments against vitamin D supplementation to rest. It demonstrated up to 40% reduction of energy production in the muscles of animals deficient in vitamin D, in spite of unchanged number/size/density of mitochondria inside the cells. In addition, it demonstrated decrease in lean mass in the deficient … Read more

Niacinamide improves glucose metabolism and muscle health in humans

Niacinamide probably does not need in introduction to the people reading my posts. However, despite the multitude of animal studies demonstrating beneficial effects of this vitamin in virtually every chronic condition (and especially conditions associated with disturbed glucose metabolism), human studies with it are very scarce. The study below is one of those rare human … Read more

Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration

A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much to the chagrin of the medical industry, the increased dietary … Read more