Dietary PUFA in childhood causes diabetes and irreversible (male) infertility

A great study, which corroborates the discussion in another recent post of mine on PUFA’s role in infertility and insulin-resistance / diabetes. However, the study below found that the infertility caused by dietary PUFA exposure were NOT reversible upon discontinuation of the high-fat (both PUFA and MUFA) diet, while previous studies found that the infertility … Read more Dietary PUFA in childhood causes diabetes and irreversible (male) infertility

Melanoma defined by increased fatty acid synthesis and unsaturation

Yet another study implicating dysregulated fatty acid, instead of glucose, metabolism in cancer cells. Namely, the expression and activity of the enzyme fatty acid synthase (FASN) is increased in melanoma cells. Another interesting finding of the study is the increased unsaturation of the accumulated fats inside the tumor. The FASN enzyme synthesizes palmitic acid (PA) … Read more Melanoma defined by increased fatty acid synthesis and unsaturation

SFA / MUFA are preferentially oxidized, while PUFA are stored/accumulated

Just a quick post in response to some of the hate mail I keep getting on a daily basis in regards to the body’s discriminatory treatment of various fat types. According to various proponents of keto diets, fasting, etc the organism has no preference for one type of fat or another in terms of oxidation … Read more SFA / MUFA are preferentially oxidized, while PUFA are stored/accumulated

Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration

A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much to the chagrin of the medical industry, the increased dietary … Read more Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration