Reduced pyruvate and/or increased lactate drive heart failure

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of heart failure. The study below demonstrates that heart … Read more Reduced pyruvate and/or increased lactate drive heart failure

Low energy production (glucose metabolism) may cause andropause

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more Low energy production (glucose metabolism) may cause andropause

The Cure for Aging Might be the Cure for Alzheimer’s

Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure of the other. http://raypeat.com/articles/articles/alzheimers.shtml … Read more The Cure for Aging Might be the Cure for Alzheimer’s

Low, not high, metabolism creates oxidative stress

A hugely popular tenet of the “rate of living” theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental health disorders. However, the explanation of higher ROS … Read more Low, not high, metabolism creates oxidative stress

Red light therapy for Parkinson Disease (PD) begins human trials

A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another branch of medicine – … Read more Red light therapy for Parkinson Disease (PD) begins human trials

Progesterone – not a sex hormone, but a systemic health hormone

An older study, but some great information in there. Not only does it call attention to the fallacy of progesterone being nothing more than a “sex” hormone, but it also warns about the fallacy of equating the synthetic progestins with bioidentical progesterone. At least, when it comes to vascular/heart/muscle effects. Over the last 15 years … Read more Progesterone – not a sex hormone, but a systemic health hormone

Low metabolism, cellular debris may cause Huntington Disease (HD)

Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular debris in the blood stream is anything but benign. The presence of such debris is interpreted by … Read more Low metabolism, cellular debris may cause Huntington Disease (HD)

Cardiolipin supplementation may reverse signs of aging

One of the key features of aging is the decline in mitochondrial function (metabolism), and that fact is widely recognized even by mainstream medicine. However, doctors still claim that the relationship between metabolic decline and aging has not be elucidated and a causative link cannot be established (yet). In other words, we don’t know if … Read more Cardiolipin supplementation may reverse signs of aging

Restoring energy production in immune cells is therapeutic in cancer

The title of the popular press article is kind of the reverse of mine – i.e. cancer cells evade treatment by blocking energy production in immune cells (T-cells). However, my title still holds since the actual study did show that restoring energy production in T-cells restores the effectiveness of immune-boosting therapies for cancer. Either way, … Read more Restoring energy production in immune cells is therapeutic in cancer

Low Dose Lithium May Stop Alzheimer’s Disease (AD) in Its Tracks

This study was sent to me by one of my Twitter followers. In some of my past interviews/podcasts, I did mention isolated published case studies, as well as anecdotal medical reports of even advanced cases of AD getting rapidly reversed by micro-dosing regimens using lithium salts such as aspartate or orotate. The doses reported by … Read more Low Dose Lithium May Stop Alzheimer’s Disease (AD) in Its Tracks