Human study – vitamin B1 safe & effective for preventing & treating Alzheimer Disease (AD)

A remarkable study, that for some reason is not being covered by mainstream media. Considering 99% of the clinical trials for AD since 2000 have completely failed, this study should be front-page news for most mainstream outlets. I suspect mainstream media, being literally owned by the same interests that own Big Pharma, finds it too … Read more

Metabolically, children are different species compared to adults

A great study, which once again puts metabolism in the spotlight. Many studies have tried to discover the main biological differences between children and adults and so far none of them have discovered a “smoking gun”. At the same time, multiple studies have demonstrated that children are much more resilient to both infections and “adult” … Read more

Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

More evidence that yet another “incurable” condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies (and discussed on this blog) to be due primarily to chronic stress. … Read more

Aging is an energy deficiency problem, taking cardiolipin may reverse it

Yet another study demonstrating that “aging” is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a mitochondrial dysfunction problem. Conversely, reversing that energy/mitochondrial deficiency … Read more

Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer – no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from which all other tissues/organs … Read more

Muscle weakness / wasting linked to poor mitochondrial function

A study that once again illustrates the central principle of bioenergetics – structure and function cannot be separated. They are interdependent at every level. In this specific case, the “structural” pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when evaluating such condition, will look for structural problems such as genetic mutations, trauma, … Read more

DHEA causes fat-loss and improved glucose metabolism in humans

Another study corroborating the role of DHEA as one of the “youth” hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are probably the reason behind its effects on decreasing … Read more

Almost half of obese adults are (metabolically) healthy

A seemingly contradictory title, but only to people who are not aware of the so-called “obesity paradox“. As I have mentioned in the past, usage of the word “paradox” usually implies a very inconvenient truth that threatens the profits of one or more branches of mainstream medicine. In this case of the obesity “paradox”, it … Read more

Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited therapeutic effects for PD patients and invariably become ineffective after a few years of use. … Read more

Inhibiting respiration/metabolism reliably causes bipolar disorder

Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport chain (ETC). The chronic, low-dose administration reliably reproduced … Read more