Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited therapeutic effects for PD patients and invariably become ineffective after a few years of use. … Read more

Inhibiting respiration/metabolism reliably causes bipolar disorder

Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport chain (ETC). The chronic, low-dose administration reliably reproduced … Read more

Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating symptoms (or even death) in people with “inborn” mitochondrial … Read more

PUFA promote torpor / hibernation, decrease lifespan

Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly controlled amounts/seasons) and universally avoided by non-hibernating ones … Read more

Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is “essential”. Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the well-known PUFA metabolites known as prostaglandins. However, … Read more

Niacinamide as treatment for scleroderma (systemic sclerosis)

Yet another “incurable” disease has been demonstrated to be nothing more but energetic deficiency in disguise. According to mainstream medicine, scleroderma (also known as systemic sclerosis) is an incurable chronic, autoimmune, progressive, fibrotic disease that attacks virtually all organs and can lead to significant disability and even death if it affects some of the more … Read more

Reduced pyruvate and/or increased lactate drive heart failure

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of heart failure. The study below demonstrates that heart … Read more

Low energy production (glucose metabolism) may cause andropause

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more

The Cure for Aging Might be the Cure for Alzheimer’s

Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure of the other. … Read more

Low, not high, metabolism creates oxidative stress

A hugely popular tenet of the “rate of living” theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental health disorders. However, the explanation of higher ROS … Read more