Uncoupling metabolism/OXPHOS may treat inflammatory conditions

In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the injury/infection due to lack of sufficient energy reserves. The … Read more

Cartilage/bone health depends on oxidative metabolism

A good study that demonstrates yet another “structural” aspect of health – the strength and growth or our cartilage/bones – is heavily dependent on proper mitochondrial function. As such, even minor disruptions of oxidative metabolism can lead to long-term deformations in bone/cartilage, which is often corroborated by the facial deformities and other bone pathologies in … Read more

Vitamin B1 and/or biotin may treat Huntington Disease (HD)

As some of my own studies with cancer recently demonstrated, vitamins are no laughing matter when it comes to their ability to treat very serious conditions. This seems to be especially true in regards to the B vitamins, which are required co-factors for most of the metabolic reactions inside our organisms. The study below adds … Read more

Alzheimer’s patients have lower metabolic rate and higher fatty acid oxidation

Just a quick post in regards to a study that found the drug donepezil – commonly used to “treat” Alzheimer’s Disease (AD) – may improve mitochondrial function in muscles. While the findings of the study in regards to donepezil are debatable and not particularly interesting, buried inside the actual study is the finding that AD … Read more

Human study – vitamin B1 safe & effective for preventing & treating Alzheimer Disease (AD)

A remarkable study, that for some reason is not being covered by mainstream media. Considering 99% of the clinical trials for AD since 2000 have completely failed, this study should be front-page news for most mainstream outlets. I suspect mainstream media, being literally owned by the same interests that own Big Pharma, finds it too … Read more

Metabolically, children are different species compared to adults

A great study, which once again puts metabolism in the spotlight. Many studies have tried to discover the main biological differences between children and adults and so far none of them have discovered a “smoking gun”. At the same time, multiple studies have demonstrated that children are much more resilient to both infections and “adult” … Read more

Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

More evidence that yet another “incurable” condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies (and discussed on this blog) to be due primarily to chronic stress. … Read more

Aging is an energy deficiency problem, taking cardiolipin may reverse it

Yet another study demonstrating that “aging” is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a mitochondrial dysfunction problem. Conversely, reversing that energy/mitochondrial deficiency … Read more

Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer – no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from which all other tissues/organs … Read more

Muscle weakness / wasting linked to poor mitochondrial function

A study that once again illustrates the central principle of bioenergetics – structure and function cannot be separated. They are interdependent at every level. In this specific case, the “structural” pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when evaluating such condition, will look for structural problems such as genetic mutations, trauma, … Read more