SHBG may be a good test for liver (metabolic) health

A very good study, which probably runs counter to the “mantra” most bodybuilders adhere to – i.e. they would say one must keep their SHBG low in order to increase levels of “free” steroids since, the claim goes, only free steroids are active and capable of influencing cells. If SHBG is high, the claim is … Read more

Oral allopregnanolone coming soon to a pharmacy near you

Kidding aside, it looks like pharma companies are starting to develop a very strong interest in oral delivery of steroids, using the technique described by Peat decades ago to bypass the first-pass metabolism in the liver. Namely, as Peat described, mixing a steroid (or another molecule) with long(er) chain fats (chain length 12 or more) … Read more

For most individuals, the risks of keto diets outweigh the benefits

The title is the actual conclusion of the study, in the authors’ own words. Among the diseases they claim keto diets cause are colon cancer, CVD, kidney disease, liver disease, Alzheimer Disease (AD) and…diabetes! If there is one disease keto diets are supposed to help with preventing and even treating, that is diabetes. The very … Read more

Iron supplementation may not cure anemia, unless nutrition is also improved

As many of my readers know, Peat is against supplementing with isolated iron. Aside from the well-known toxicity risks (e.g. liver damage) multiple studies have shown that in a good portion of the people treated with oral iron supplements, anemia either does not resolve or rapidly returns upon stopping the supplements. This is most likely … Read more

Cortisol causes fatty liver (as well as obesity, diabetes, etc)

Not really a surprise for most of my readers, but it is always nice to see more evidence establishing various disorders attributed to “gluttony”, “weak will”, “addiction”, etc as actual endocrine disturbances. And since the current study implicates cortisol, we can point the finger once again at (chronic) stress. While the current study mostly focused … Read more

Oral testosterone + vitamin E may treat NAFLD, NASH, cirrhosis in humans

Several years ago, I posted a few studies from the 1970s demonstrating very high cure rates of advanced cirrhosis in humans with a combination treatment of testosterone (T) and vitamin B1 (thiamine). Not bad for a condition modern medicine tells us is incurable and the only option the patient has is a liver transplant. https://pubmed.ncbi.nlm.nih.gov/14139786/ … Read more

Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also established a minimum daily dosage needed to … Read more

Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a catabolic steroid) is, naturally, a potent inducer of those … Read more

Alcohol causes liver (and other organ) damage by lowering NAD/NADH ratio

A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the start of the “pandemic” have exacerbated dramatically. As most … Read more