lipolysis

Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

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Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream effects. Now, if the fat released as a result of the increased lipolysis was fully saturated … Read more Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

Keto diet can cause lethal kidney failure

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The bad news for the low-carb diets just keep piling on. This case report is about a young and (presumably) healthy Indian actress, which quickly deteriorated and eventually died of kidney failure while subjecting herself to the keto diet. Before the hate mail starts pouring into my mailbox, please read the article as it explains … Read more Keto diet can cause lethal kidney failure

PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

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A few months ago I posted about a study discussing the role of lipid peroxidation in the COVID-19 pathology. While that study did not make any statements about effects of diet on the disease course/outcome, it did suggest lipid peroxidation blockers such as vitamin E would be therapeutic. Now, we have another study that points … Read more PUFA exacerbate, saturated fats (SFA) / albumin / calcium ameliorate COVID-19

Lipolysis / FFA drive breast cancer by promoting estrogen signalling

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The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the expression/activity of one promotes the other as well. … Read more Lipolysis / FFA drive breast cancer by promoting estrogen signalling

SFA / MUFA are preferentially oxidized, while PUFA are stored/accumulated

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Just a quick post in response to some of the hate mail I keep getting on a daily basis in regards to the body’s discriminatory treatment of various fat types. According to various proponents of keto diets, fasting, etc the organism has no preference for one type of fat or another in terms of oxidation … Read more SFA / MUFA are preferentially oxidized, while PUFA are stored/accumulated