Hypogonadism in older males due to low OXPHOS

I suspect many readers will simply say “duh!”, but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the actual cause of this decline in androgens in the first place … Read more

Age-related steroid deficiency may be treatable with niacinamide

The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am posting this study not so … Read more

Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

A very interesting and very “controversial” (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine “mysteries” becoming more common among the male population of “developed” … Read more

Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and relatives who struggled to conceive, and it is … Read more

Low DHT can cause hypogonadism symptoms even in eugonadal men

Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and “aging male” syndrome. For every 10% increase in DHT levels there was a 4.67% decrease in hypogonadism symptoms of … Read more

Oral pregnenolone as hormone replacement therapy (HRT) in humans

As many of my readers know, the first step in steroid synthesis is the so-called “side-chain cleavage”, which converts cholesterol into pregnenolone (P5). That step is known as the rate-limiting step in the steroid cascade, and its function depends on the redox status and ATP levels. In other words, the rate-limiting step of steroid synthesis … Read more

Low energy production (glucose metabolism) may cause andropause

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more

Endotoxin has a G.E.L.D.I.N.G effect, causes obesity and hypogonadism

A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable similarities in the phenotypes caused by castration and chronic endotoxemia. While … Read more

Endocrine disruptors in sunscreen absorb systemically after just one day of use, persist for days

So much for the safety of sunscreen. Of course, the article immediately goes on the defensive and warns against stopping sunscreen. It even includes gems like “The sun is the real enemy here” and keeps repeating the mantra that it is all about risk-benefits analysis. Yet, even MSM is forced to admit that the several … Read more