Stress (cortisol) causes hair loss

Amazing study, which perfectly corroborates the findings of a previous study showing that estrogen (a cortisol promoter) also causes hair loss, while administering an estrogen-blocker reversed the hair loss. Administration of androgens (known cortisol and estrogen blockers) such as testosterone had similar effects, and even the “hair villain” DHT robustly promoted hair growth. Cortisol is … Read more

Childhood stress causes mental illness in adults by blunting androgens

Yet another great study solidifying the evidence on just how detrimental early childhood stress is. It has been known for decades that childhood stress leads to early puberty, and that the latter is associated with greatly increased risk of chronic diseases later in life, as well as early death. However, mainstream medicine has always heatedly … Read more

Stress (cortisol) as the driver of hyperglycemia in type II diabetes

To most of my readers, the title of the post may seem like something completely obvious and not deserving explanation of clarification. However, according to mainstream medicine (until now, at least) cortisol does not really have a causative role either in the development of diabetes type II or in its various manifestations such as obesity, … Read more

Sexual activity and stress levels (HPA activity) may determine longevity

The study below tried to tease out the main factors affecting the longevity of the legendary naked mole rat – the animal with longest lifespan in its genus, and the sole mammal known to be virtually immune to developing cancer. Most of the biological/biochemical findings in regards to naked mole rats have already been found … Read more

Studies in animals often use stressful methods that produce invalid results

Back in 2012, when I first started writing about the benefits of steroids such as pregnenolone, I often got emails quoting the study below as evidence that pregnenolone and related steroids amplify instead of mitigate the stress response (HPA axis). https://www.ncbi.nlm.nih.gov/pubmed/17928160 “…We chose IP injection to assess neuroactive steroids effects at the central level because … Read more

How chronic stress (cortisol) causes disease

Back in 2018 I did a post on a neat study that demonstrated how the presence of cellular (mitochondrial) fragments in the blood stream acts identically to the pituitary hormone ACTH and as such activates the HPA axis. The more cellular fragments are in the bloodstream the more intense the stress response from the adrenals. … Read more