Studies in animals often use stressful methods that produce invalid results

Back in 2012, when I first started writing about the benefits of steroids such as pregnenolone, I often got emails quoting the study below as evidence that pregnenolone and related steroids amplify instead of mitigate the stress response (HPA axis). https://www.ncbi.nlm.nih.gov/pubmed/17928160 “…We chose IP injection to assess neuroactive steroids effects at the central level because … Read more Studies in animals often use stressful methods that produce invalid results

How chronic stress (cortisol) causes disease

Back in 2018 I did a post on a neat study that demonstrated how the presence of cellular (mitochondrial) fragments in the blood stream acts identically to the pituitary hormone ACTH and as such activates the HPA axis. The more cellular fragments are in the bloodstream the more intense the stress response from the adrenals. … Read more How chronic stress (cortisol) causes disease