Vitamin B1 can reverse heart damage/failure caused by alcoholism

The beneficial effects of vitamin B1 (thiamine) on the nervous system have been known for a long time, and the vitamin is routinely used in hospitals around the world to treat both acute alcohol intoxication as well as the nervous system damage known as Wernicke-Korsakoff syndrome caused by chronic alcohol abuse. It has been known … Read more

Reduced pyruvate and/or increased lactate drive heart failure

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of heart failure. The study below demonstrates that heart … Read more

Forcing the heart to burn glucose instead of fat may cure heart failure

One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an organism can have profound structural effects, … Read more

Sterilizing the gut may treat heart failure

Yet another study showing the key role of endotoxin (LPS) in “irreversible” and lethal conditions such as heart failure. It is also yet another study to suggest that there may be no such a thing as “beneficial” gut bacteria, as any strain capable of producing endotoxin likely contributes to development/progression of chronic disease, and most … Read more

PUFA (metabolites) drive heart failure and possibly diabetes

Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin synthesis while LOX enzymes are responsible for leukotriene … Read more

Vitamin D deficiency can cause heart failure

As many readers know, there is an epidemic of vitamin D deficiency. It is of worldwide proportions, but is visible mainly in “developed” countries in the Western world. The official stance of mainstream medicine is that while vitamin D deficiency is undesirable, it does not really have much clinical relevance except for older people at … Read more

Heart failure deaths on the rise in younger US adults

The bad news for younger Americans just keep on coming. In addition to lethal cancers, diabetes, stroke, CVD, infertility, etc now we can add yet another “old man” disease to the list of banes inflicting the “young”. Heart failure is a condition traditionally seen in people 65 and older, and mortality from it has been … Read more