How lipolysis may damage organs such as the heart

It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in most obese people, and especially in people with diabetes. … Read more

DHT, not T, likely the “active” androgen in heart and brain

Interesting study, done on baboons (so should have good relevance for humans), demonstrating that the cardiovascular system (CVS) exclusively accumulates and recognizes (at the receptor level) DHT, instead of testosterone (T). In fact, the androgen receptor in CVS is so structurally different it apparently cannot even bind T. Recent studies with ALS patients suggest the … Read more

Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below provides the first direct evidence that … Read more

Vitamin E restores cardiac health after heart attack

A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the start in a way … Read more

The people with the world’s healthiest hearts eat a 70%+ carbohydrate diet

So much for carbs making you fat, diabetic, sick and old. This is a nice corroboration of the other thread I posted on Okinawan diet. The author of this study actually mentions the Okinawan people as second-most-healthy in terms of cardiovascular system. The Tsimane diet has the same amount of protein as the Western diets … Read more

Niacinamide may help treat/reverse heart disease

Yet another study showing the beneficial effects of improving mitochondrial function. This time, the study looked at heart health and found that NAD precursors like niacinamide and nicotinamide riboside (NR) can help prevent the decline in mitochondrial function and oxygen consumption driven by various stresses, including toxic assaults and calcium overload. The study showed that … Read more