Glucose is anabolic for thymus, opposes catabolic effects of cortisol

As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone and even DHT (but not by testosterone). The study below confirms the catabolic effects of cortisol … Read more Glucose is anabolic for thymus, opposes catabolic effects of cortisol

Down Syndrome (DS) cognitive handicap is due to (cellular) stress, may be reversible

If there is any disease that is currently considered incurable even in principles, it likely comes from the group of inherited/genetic disorders. Perhaps the most well-known one, due to rapidly rising incidence and thus publicity, is DS. Perhaps its most disabling aspect of DS is the cognitive dysfunction that manifest in such patients. The bulk … Read more Down Syndrome (DS) cognitive handicap is due to (cellular) stress, may be reversible

Mitochondrial damage and fatty acid buildup, not elevated glucose, may drive diabetes

Finally some common sense is coming out of mainstream medicine. The study below demonstrates that it is the buildup of fatty acid metabolites and mitochondrial damage that drives the chronic inflammation now known to be a major causative factor for diabetes II (T2DM). Aside from corroborating the role of fat in diabetes, as well as … Read more Mitochondrial damage and fatty acid buildup, not elevated glucose, may drive diabetes

MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

ALS tied to increased fat oxidation (FAO), increasing glucose may treat it

I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings strongly suggest ALS is linked to stress and dysregulated metabolism. … Read more ALS tied to increased fat oxidation (FAO), increasing glucose may treat it