To Extract Knowledge from Matter
Perceive, Think, Act
A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating symptoms (or even death) in people with “inborn” mitochondrial … Read more
A great human study on the beneficial effects of androgens for a variety of metabolic biomarkers associated with insulin resistance and diabetes II. The only gripe I have with this study is that they claim it was conducted with “healthy” men when in reality all men had low plasma total testosterone (PTT), which of course … Read more
The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is “essential”. Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the well-known PUFA metabolites known as prostaglandins. However, … Read more
As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more
One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an organism can have profound structural effects, … Read more
As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone and even DHT (but not by testosterone). The study below confirms the catabolic effects of cortisol … Read more
If there is any disease that is currently considered incurable even in principles, it likely comes from the group of inherited/genetic disorders. Perhaps the most well-known one, due to rapidly rising incidence and thus publicity, is DS. Perhaps its most disabling aspect of DS is the cognitive dysfunction that manifest in such patients. The bulk … Read more
Finally some common sense is coming out of mainstream medicine. The study below demonstrates that it is the buildup of fatty acid metabolites and mitochondrial damage that drives the chronic inflammation now known to be a major causative factor for diabetes II (T2DM). Aside from corroborating the role of fat in diabetes, as well as … Read more
Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS – i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology. Well, hot on the heels of that study is the study below, which found very similar … Read more
I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings strongly suggest ALS is linked to stress and dysregulated metabolism. … Read more