glucocorticoid

Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

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A really interesting study, which will likely generate more than a few hateful emails for my Inbox 🙂 Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER) and glucocorticoid receptor (GR). So, aside from the important … Read more Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

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In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a catabolic steroid) is, naturally, a potent inducer of those … Read more Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

High cortisol and low testosterone likely drive PTSD

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As the article below states, 20%+ of service members come back with PTSD. It is a devastating mental condition that makes patients not only unable to participate meaningfully in society but often drives them to violent and homicidal/suicidal behavior. Given the roles of cortisol and serotonin in driving violent psychotic behavior, the etiology of PTSD … Read more High cortisol and low testosterone likely drive PTSD