fatty acid synthase

Melanoma defined by increased fatty acid synthesis and unsaturation

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Yet another study implicating dysregulated fatty acid, instead of glucose, metabolism in cancer cells. Namely, the expression and activity of the enzyme fatty acid synthase (FASN) is increased in melanoma cells. Another interesting finding of the study is the increased unsaturation of the accumulated fats inside the tumor. The FASN enzyme synthesizes palmitic acid (PA) … Read more

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

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Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more