Cancer relies on fat as fuel due to high reductive stress

One of the few studies out there that not only links cancer with impaired OXPHOS, but demonstrates directly the role of reductive stress (exemplified by the NAD/NADH ratio) in cancer’s appetite for fats as fuel required for the cancer survival and proliferation/metastasis. It also once again demonstrates the falsehood of the popular term “oxidative” stress, … Read more

Higher PUFA intake correlated with mental disease

An epidemiological study, yet still useful IMO since the correlation was maintained across the various levels of PUFA intake – i.e. the higher the PUFA intake the higher the prevalence of a mental disorder such as depression, which suggests a causal link. The link was the strongest in males and increased with age in both … Read more

Oral allopregnanolone coming soon to a pharmacy near you

Kidding aside, it looks like pharma companies are starting to develop a very strong interest in oral delivery of steroids, using the technique described by Peat decades ago to bypass the first-pass metabolism in the liver. Namely, as Peat described, mixing a steroid (or another molecule) with long(er) chain fats (chain length 12 or more) … Read more

DHEA causes fat-loss and improved glucose metabolism in humans

Another study corroborating the role of DHEA as one of the “youth” hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are probably the reason behind its effects on decreasing … Read more

Fasting ineffective for shrinking belly fat, may actually increase it

Hopefully, this study will give some serious food for thought to people who use (intermittent) fasting (IF) with the goal of losing excess weight. A recent post of mine discussed that IF is ineffective for fat loss and actually leads to loss of lean mass. The lead author of that study, himself an IF practitioner … Read more

Dietary fat, not carbs or protein, makes people fat

The study below adds some evidence to the debate that is has been raging for decades – i.e. just what dietary component contributes the most to weight gain. The current favorite “villain” of clinical nutrition are carbohydrates, especially their easily digestible form such as sucrose, fructose, glucose, lactose, etc. The public space is littered with … Read more

Burning more fat and less glucose leads to diabetes

I really hope the keto community and other low-carb diet afficionados are taking note of the stream of recent studies that keep demonstrating a causative link between low-carb and/or high-fat diets, fasting, chronic stress, cortisol and diabetes. The evidence at this point is indisputable, no matter how much effort the medical industry puts into trying … Read more

PUFA are immunosuppressive, fasting and protein restriction (possibly) even more so

Several great studies, which quickly illustrate the connection between PUFA, immune system, estrogen, cortisol, cancer and the protective role vitamin A/E play as well as their likely mechanism(s) of action. As I mentioned on one of the first podcasts with Danny Roddy, the role of PUFA as immunosuppressants is actually well-known in the organ transplant … Read more

Mitochondrial damage and fatty acid buildup, not elevated glucose, may drive diabetes

Finally some common sense is coming out of mainstream medicine. The study below demonstrates that it is the buildup of fatty acid metabolites and mitochondrial damage that drives the chronic inflammation now known to be a major causative factor for diabetes II (T2DM). Aside from corroborating the role of fat in diabetes, as well as … Read more