Melanoma defined by increased fatty acid synthesis and unsaturation

Yet another study implicating dysregulated fatty acid, instead of glucose, metabolism in cancer cells. Namely, the expression and activity of the enzyme fatty acid synthase (FASN) is increased in melanoma cells. Another interesting finding of the study is the increased unsaturation of the accumulated fats inside the tumor. The FASN enzyme synthesizes palmitic acid (PA) … Read more Melanoma defined by increased fatty acid synthesis and unsaturation

Increased fatty acid synthesis (FAS) is simply a sign of oxygen deficiency / low metabolism

Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can “paradoxically” result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that demonstrated the same effect … Read more Increased fatty acid synthesis (FAS) is simply a sign of oxygen deficiency / low metabolism

Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)

The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an “effect” is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg “Effect” term was coined, the evidence rapidly accumulates that the lactic acidosis is not at … Read more Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)

Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality – sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it may be more appropriate to … Read more Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate