COVID-19 is an energy deficiency disease

Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably increase the production of reactive oxygen species (ROS), which is known to … Read more

Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer – no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from which all other tissues/organs … Read more

Inhibiting respiration/metabolism reliably causes bipolar disorder

Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport chain (ETC). The chronic, low-dose administration reliably reproduced … Read more