An estrogen antagonist treats many cancers, including triple-negative breast cancer

Just a portion of the title is already paradoxical, according to mainstream medical dogma. Namely, how can an estrogen antagonist treat triple-negative breast cancer that is supposedly fully immune to any hormonal effects!? Well, maybe the whole idea of hormonal “receptors” as the only mechanism through which hormones exert their effects on cells is rather … Read more

Higher progesterone, lower estrogen makes women more generous

It looks like the beneficial effects if progesterone and harmful effects of estrogen are not limited to health. The study below found a women become much more generous in terms of buying drinks or gifts for their peers during the luteal phase, when progesterone is elevated and estrogen is low. If progesterone and estrogen are … Read more

DHT blocks, androgen antagonists promote breast cancer

The first claim of the title is already well-known to my readers and to clinical practice. DHT was clinically used back in the middle of the 20th century as a treatment for breast cancer, and the synthetic androgen Drostanolone (Masteron), which still retains its approval by FDA for breast cancer treatment, is a simple DHT … Read more

Stearic acid (SA) is an estrogen receptor antagonist

Over the last year or so I stumbled upon a few studies claiming both SA (C18:0) and its methyl ester are capable of binding the estrogen receptors (ER) and modulate their transcription effects. However, those studies did not evaluate if SA acted as an agonist or antagonist on those receptors. So, I did a little … Read more

Estrogen may cause/exacerbate reflux disease (GERD)

A very interesting study, which once again corroborates the hypothesis that there is no chronic condition, which is not either caused or heavily influenced by steroids. Among the conditions medicine considers not to be linked to hormone imbalances is the extremely common “reflux disease”, medically known as GERD. The official dogma is that GERD is … Read more

Alzheimer’s Severity Tied to Longer Estrogen Exposure in Women

A neat study, which somehow managed to slip through my “radar” when it was first published the middle of last (2021) year. The study is pretty straighforward in its claim that longer exposure to endogenous estrogen was associated with exacerbated/higher biomarkers of Alzheimer disease (AD), as well as lower glucose metabolism and smaller brain volume … Read more

Estrogen promotes, progesterone inhibits drug (cocaine) abuse

An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact opposite (acts as a glutamate antagonist and GABA agonist). … Read more

Estrogen associated with arterial stiffness in women

Blood pressure rises with age, and most people over the age of 50 are on some type of blood pressure controlling medication. It is well-known that blood vessels calcify/stiffen with age and that such stiffness is what leads to increased blood pressure – i.e. the inability of vessels to expand/relax during increased heart activity. This … Read more

Scoliosis (even in females) may be driven by low androgen levels, DHT may treat it

I am posting about this condition as it seems recently its numbers have absolutely exploded in the general population. Scoliosis used to be a relatively uncommon condition, usually present in adults over the age of 50. Mainstream medicine has no explanation for its possible causes, but suspects inflammation is involved. The study below suggests that … Read more

Cancer cells deprive immune cells of energy by devouring their mitochondria

In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer cells using tiny, nano-sized tentacles (a trunk … Read more