Maternal high-PUFA diet causes alcoholism, aggressiveness, early puberty, and hyper-estrogenism in offspring

Finally, an intervention study that should help convince some of the die-hard PUFA fans that these fatty acids are far from benign/beneficial, but in fact can cause a variety of chronic diseases. A very important finding of the study, that distinguishes it from other PUFA studies, is that it demonstrates without a doubt the estrogenicity … Read more

Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and relatives who struggled to conceive, and it is … Read more

Estrogens cause obesity / PCOS in women, DHT is protective

Female obesity and the closely related condition PCOS are perhaps the female equivalent of the so-called “androgen hypothesis” for balding and prostate cancer in men, as the female version of this hypothesis not only blames androgens for these conditions but specifically singles out DHT as the main “villain”. The mainstream medical dogma is that a … Read more

Even “non-carcinogenic” estrogens can cause cancer

I know, the title is a “paradox”, but this is truly what the article discusses. By now, we already know that the word “paradox” in science is just a euphemism for idotism and/or fraud. Apparently, mainstream medicine has managed to convinced the public somehow that there are carcinogenic and non-carcinogenic estrogens. An example of the … Read more

DHT is an estrogen (receptor) antagonist

A neat little study, and in-vivo at that, which demonstrates that DHT is a direct estrogen receptor (ER) antagonist. According to the study, so are testosterone, nandrolone and a few other steroids with demonstrated therapeutic effects on ER-positive breast cancer (BC). However, all of the other steroids mentioned by the study are aromatizable and as … Read more

Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

A really interesting study, which will likely generate more than a few hateful emails for my Inbox 🙂 Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER) and glucocorticoid receptor (GR). So, aside from the important … Read more

Lowering estrogen prevents memory decline in menopausal females

As many of my readers know, the WHI studies were highly detrimental to the profits of the estrogen industry. Every since the results of those studies came out, the estrogen industry has been trying to undermine the findings and re-introduce estrogen HRT for women with the claims that estrogen is highly beneficial if used in … Read more

Estrogen can both cause and exacerbate Lupus

A quick post as a response to a recent argument I had over email with an endocrinologist who follows me on Twitter. His claim was that the causes of Lupus are currently unknown but are likely “multifactorial” and me ascribing such causes to “isolated peculiarities” such as endotoxin (LPS) or estrogen is unwarranted. The fact … Read more

Estrogen may be the cause of “estrogen-negative” breast cancer

IMO, one of the biggest medical frauds so far is the idea that androgens (especially DHT) cause and promote prostate cancer. We now have an abundance of evidence (posted on this blog) that it is instead deficiency of androgens and/or excess of estrogens that initiates and drives the progression of prostate cancer. When chemical castration … Read more

Androgens boost, estrogen inhibits, anti-aging gene Klotho

This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR) agonism, the more robustly it increases Klotho. Conversely, the most potent the … Read more