Androgens boost, estrogen inhibits, anti-aging gene Klotho

This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR) agonism, the more robustly it increases Klotho. Conversely, the most potent the … Read more Androgens boost, estrogen inhibits, anti-aging gene Klotho

Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

I am posting this study below as a response to numerous angry emails I have been getting over the years. People sending me those emails just cannot accept the idea that estrogen can be detrimental for males (and females as well), and that estrogen levels are directly antagonistic to the male phenotype. This “‘male antagonism” … Read more Estrogen lowers T, DHT, and fertility; inhibits 5α-Reductase (5-AR)

Irritable bowel syndrome (IBS) caused by histamine and serotonin

I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones – i.e. there are … Read more Irritable bowel syndrome (IBS) caused by histamine and serotonin

Aromatase inhibitor (AI) + DHT combo may reverse kidney disease (CKD)

A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is virtually unknown in endocrinology circles. In fact, there have … Read more Aromatase inhibitor (AI) + DHT combo may reverse kidney disease (CKD)

Lipolysis / FFA drive breast cancer by promoting estrogen signalling

The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the expression/activity of one promotes the other as well. … Read more Lipolysis / FFA drive breast cancer by promoting estrogen signalling

Estrogen directly causes polycystic ovary syndrome (PCOS)

The worldwide rates of PCOS are skyrocketing, and have more than doubled over the last 10 years. Currently, about 12% of women in child-bearing age living in “developed” countries have PCOS and as a result struggle with infertility, diabetes, CVD, acne, bone issues, and even cancer. The fact that infertility is almost always present in … Read more Estrogen directly causes polycystic ovary syndrome (PCOS)

Male sexual function does NOT require estrogen

It is a “sacred” mantra in the medical and sports worlds – i.e. “estrogen is crucial for males, without it they won’t have any sex life”. This mantra is also part of the justification given for the currently ongoing COVID-19 clinical trials with males receiving estrogen in the hope it will reduce the lethality of … Read more Male sexual function does NOT require estrogen

Estrogen and histamine, not HPV, drive cervical cancer

A few months ago, I did a post about a study which made the bold claim that estrogen instead of HPV is the actual cause of the (often deadly) cervical cancer. According to that study, HPV infection is at best permissive and at worst simply an (largely innocent) bystander. A statement like this is absolute … Read more Estrogen and histamine, not HPV, drive cervical cancer

Estrogen, not androgens, may be the cause of baldness

A quick post about a study calling into question yet another dogma in medicine – i.e. that the “evil” androgens (especially DHT) are the causes of men losing their hair and getting prostate cancer. So, the “solution” modern medicine proposes is “chemical castration” with drugs like finasteride, dutasteride, flutamide, bicalutamide, etc that render men impotent, … Read more Estrogen, not androgens, may be the cause of baldness

Anti-histamines may prevent, treat melanoma

About 2 years ago I did a post discussing the hypothesis that melanoma is an endocrine tumor, similar to breast cancer – i.e. driven by estrogen. In fact, if one has the time to dig into the published literature on all known malignancies, it quickly becomes apparent that virtually all cancers can be classified as … Read more Anti-histamines may prevent, treat melanoma