Inhibiting respiration/metabolism reliably causes bipolar disorder

Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport chain (ETC). The chronic, low-dose administration reliably reproduced … Read more

Niacinamide may treat depression by improving energetic state

A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without the SIRT1 gene were highly resistant to depression and had high … Read more

Vitamin D prevents cortisol-induced depression and…inflammation

A great study for a number of reasons. First, it discussed openly that in animal research circles cortisol administration is considered an official and reliable method of causing major depression. As the article states, for some reason human medical circles have been unwilling to accept the stress-depression causal link and continue to argue that stress … Read more

Meditation can worsen mental health, even cause clinical psychiatric issues

I have always been ambivalent in regards to meditation, mostly due to its teachings that many perceived problems are simply in “our head” and all we need to do as “treatment” is steer our thoughts in a particular direction. We are flooded with information/advice that once we master whatever technique the specific type of meditation … Read more

The social fabric in Western countries may be unraveling

In one of Peat’s recent newsletters he mentioned that there is an epidemic of mental disease in the population because the evil system these people live is preventing them from living their lives “meaningfully, creatively”. A recent study corroborated Peat’s writings on the truly abysmal state of mental health in young people. Add to that … Read more

Prenatal stress ups serotonin, which causes autism and mental disease in offspring

Another good study, which not only corroborates the causative role of elevated serotonin in a number of behavioral disorders in children (which extend into adulthood) but demonstrates the key role of endotoxin (LPS) in that process. Namely, the pregnant animals exposed to stress who had sterile guts were immune to the pro-inflammatory effects of stress … Read more

A third of Americans show signs of clinical anxiety, depression

The news about deteriorating health of the population just keep piling on. The latest one below shows that at least a third of the US population shows signs of clinical anxiety and/or depression. The reason I put clinical in bold is that it means the pathology is severe enough to require treatment and if left … Read more

Ketamine cures depression by reducing serotonin, increasing dopamine

As many of my readers know, FDA recently approved the party drug ketamine (known as Special-K on the street) as a rapidly-acting antidepressant. The rapid antidepressant effects of ketamine have been known since the 1960s but FDA denied that those effects are relevant in humans and refused to consider “scheduled” illicit drugs for therapeutic uses. … Read more

SSRI drugs, not depression, destroy empathy

Yet another medical myth gets busted today. A common dogma in psychiatry is that one of the core symptoms of patients with major depressive disorder (MDD) is lack of empathy. In other words, while such patients are perfectly in tune with their own suffering and negative emotions, they are indifferent (and sometimes even pleased) at … Read more

Drop in dopamine behind giving up

I would have much preferred if the authors of the study below investigated the level of serotonin and its relation to giving up (“learned helplessness” anyone?), but I suppose the dogma of serotonin is still too “sacred” to be questioned in biomedical research. So, instead of saying that elevated serotonin causes despair and giving up, … Read more