Endotoxin behind the mortality of Black Death and 1918 Flu pandemics

As many of my readers know, many/most people dying from COVID-19 develop either sepsis and/or respiratory failure. Endotoxin (LPS) is now a known cause behind both of these conditions, as a virus by itself has no known mechanism of causing a cytokine storm. As much as I revile the term “scientific consensus”, in this case … Read more Endotoxin behind the mortality of Black Death and 1918 Flu pandemics

Cytokine storm in COVID-19 / sepsis due to “cancer metabolism” (Warburg Effect)

A few great studies illustrating the crucial effects of metabolism even in “non-metabolic” conditions like COVID-19. We already have evidence that increased PUFA peroxidation is one of the causes behind the (often lethal) cytokine storm in viral diseases, including COVID-19. However, the direct mechanism through which immune cells such as phagocytes “go berserk” and increase … Read more Cytokine storm in COVID-19 / sepsis due to “cancer metabolism” (Warburg Effect)