Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

A really interesting study, which will likely generate more than a few hateful emails for my Inbox 🙂 Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER) and glucocorticoid receptor (GR). So, aside from the important … Read more Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

Ear wax testing as a reliable method for measuring long-term steroid levels

Many of my readers already know about the unreliability of using steroid blood tests as diagnostic methods, except in cases where the values are so extreme that are unlikely to be temporary fluctuations. Saliva tests for steroids are even less reliable, even though combining both saliva and blood tests usually provides more reliable information than … Read more Ear wax testing as a reliable method for measuring long-term steroid levels

Vitamin D prevents cortisol-induced depression…and inflammation

A great study for a number of reasons. First, it discussed openly that in animal research circles cortisol administration is considered an official and reliable method of causing major depression. As the article states, for some reason human medical circles have been unwilling to accept the stress-depression causal link and continue to argue that stress … Read more Vitamin D prevents cortisol-induced depression…and inflammation

Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a catabolic steroid) is, naturally, a potent inducer of those … Read more Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

PUFA is catabolic, SFA is anti-catabolic (anabolic)

During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT is induced almost exclusively by glucocorticoids and is used clinically as … Read more PUFA is catabolic, SFA is anti-catabolic (anabolic)

Blocking cortisol may treat even terminal cancers

The metabolic causes of cancer are slowly starting to be recognized, and especially the role of cortisol. I recently did a post on the role of cortisol in triple-negative breast cancer and the protective effects of androgens such as DHT. Now, mainstream medicine does not deny that androgens have therapeutic role in breast cancer (BC) … Read more Blocking cortisol may treat even terminal cancers

Stress (cortisol) can cause ANY autoimmune condition by disrupting gut barrier

A great new study that is not afraid to point out the paradox between mainstream medicine’s claims of beneficial effects of cortisol and the reality of “autoimmune” conditions more often than not being associated with elevated levels of CRH, ACTH and cortisol. The role of CRH as a causative factor in a number of chronic … Read more Stress (cortisol) can cause ANY autoimmune condition by disrupting gut barrier

Cortisol drives triple-negative breast cancer, androgens (DHT) are therapeutic

Another confirmation of a hypothesis made more than 100 years ago – i.e. all cancers are hormonally sensitive and to speak of a steroid-negative cancer is nonsense. If all cancers are driven by at least one steroid then it would make sense to discover what that steroid is and develop therapeutic interventions that block its … Read more Cortisol drives triple-negative breast cancer, androgens (DHT) are therapeutic

Aspirin/salt for treating a broken heart, and what REALLY causes Afib

At a first glance the study below seems rather mundane but a careful read provides some very interesting insights. The syndrome of “broken heart” is a real physiological condition that medicine has tried to deny for decades despite even assigning it its own official medical name – Takotsubo Syndrome (TS). People grieving over the loss … Read more Aspirin/salt for treating a broken heart, and what REALLY causes Afib

The keto diet works only for a week, then it causes obesity and diabetes

A great study that goes a long way towards dispelling the currently dominant dietary fad – the keto diet, as well as various other functionally equivalent diets such as Paleo, Warrior, intermittent fasting, etc. As the study unequivocally demonstrates, the reductions in blood sugar and weight while on a low-carb happens only during the first … Read more The keto diet works only for a week, then it causes obesity and diabetes