Glucocorticoids may increase inflammation in the long run

Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments – i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as COVID-19. The officially improved indications for those glucocorticoid drugs continue to increase … Read more Glucocorticoids may increase inflammation in the long run

Childhood stress causes mental illness in adults by blunting androgens

Yet another great study solidifying the evidence on just how detrimental early childhood stress is. It has been known for decades that childhood stress leads to early puberty, and that the latter is associated with greatly increased risk of chronic diseases later in life, as well as early death. However, mainstream medicine has always heatedly … Read more Childhood stress causes mental illness in adults by blunting androgens

Cortisol may drive COVID-19 mortality

The reason I decided to do a post on this study is that over the last several months, various public health authority bodies around the world have adopted “treatment protocols” for COVID-19 hospitalized patients, and virtually all such protocols contain a potent synthetic glucocorticoid such as dexamethasone. If the findings of the study below are … Read more Cortisol may drive COVID-19 mortality

Stress (cortisol) as the driver of hyperglycemia in type II diabetes

To most of my readers, the title of the post may seem like something completely obvious and not deserving explanation of clarification. However, according to mainstream medicine (until now, at least) cortisol does not really have a causative role either in the development of diabetes type II or in its various manifestations such as obesity, … Read more Stress (cortisol) as the driver of hyperglycemia in type II diabetes

Sugar (sucrose) lowers stress-induced cortisol

Just a quick post to give some props to the much-vilified sucrose. The study below demonstrates that sucrose consumption for just 3 days prior, blunted most of the negative effects of stress, and especially the rise in plasma cortisol. The HED of sucrose was about 4g/kg, which matches closely Peat’s recommendations that consumption of 350g-400g … Read more Sugar (sucrose) lowers stress-induced cortisol

Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline levels, combined with low levels of androgens such as testosterone and DHEA a full 6 months … Read more Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

A really interesting study, which will likely generate more than a few hateful emails for my Inbox 🙂 Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER) and glucocorticoid receptor (GR). So, aside from the important … Read more Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

Ear wax testing as a reliable method for measuring long-term steroid levels

Many of my readers already know about the unreliability of using steroid blood tests as diagnostic methods, except in cases where the values are so extreme that are unlikely to be temporary fluctuations. Saliva tests for steroids are even less reliable, even though combining both saliva and blood tests usually provides more reliable information than … Read more Ear wax testing as a reliable method for measuring long-term steroid levels

Vitamin D prevents cortisol-induced depression and…inflammation

A great study for a number of reasons. First, it discussed openly that in animal research circles cortisol administration is considered an official and reliable method of causing major depression. As the article states, for some reason human medical circles have been unwilling to accept the stress-depression causal link and continue to argue that stress … Read more Vitamin D prevents cortisol-induced depression and…inflammation

Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a catabolic steroid) is, naturally, a potent inducer of those … Read more Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury