Vitamin D may treat (opioid) “addiction”

Interesting article, which corroborated the role of vitamin D as an anti-stress hormone. As vitamin D is an actual steroid, it is expected to have a role as neurosteroid as well, and as such influence behavior and habits, including pathological ones such as “addiction”. Why do I put “addiction” in quotes? Mostly because the totality … Read more

Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and relatives who struggled to conceive, and it is … Read more

Cortisol causes fatty liver (as well as obesity, diabetes, etc)

Not really a surprise for most of my readers, but it is always nice to see more evidence establishing various disorders attributed to “gluttony”, “weak will”, “addiction”, etc as actual endocrine disturbances. And since the current study implicates cortisol, we can point the finger once again at (chronic) stress. While the current study mostly focused … Read more

DHEA causes fat-loss and improved glucose metabolism in humans

Another study corroborating the role of DHEA as one of the “youth” hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are probably the reason behind its effects on decreasing … Read more

Stress (cortisol) causes hair loss

Amazing study, which perfectly corroborates the findings of a previous study showing that estrogen (a cortisol promoter) also causes hair loss, while administering an estrogen-blocker reversed the hair loss. Administration of androgens (known cortisol and estrogen blockers) such as testosterone had similar effects, and even the “hair villain” DHT robustly promoted hair growth. Cortisol is … Read more

Blocking cortisol may treat terminal pancreatic cancer

Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed terminal case of pancreatic cancer using 200mg daily dose of RU486. … Read more

Stress (cortisol) causes pre-term birth by blocking progesterone

If you ask a gynecologist what causes premature birth, the answer will usually be something along the lines of “insufficient progesterone” often accompanied by mumbling about “genetic predispositions”. Yet, how exactly is insufficient progesterone responsible for premature birth has remained a mystery, at least for most practicing doctors. Back in the first half of the … Read more

Glucocorticoids may increase inflammation in the long run

Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments – i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as COVID-19. The officially improved indications for those glucocorticoid drugs continue to increase … Read more

Childhood stress causes mental illness in adults by blunting androgens

Yet another great study solidifying the evidence on just how detrimental early childhood stress is. It has been known for decades that childhood stress leads to early puberty, and that the latter is associated with greatly increased risk of chronic diseases later in life, as well as early death. However, mainstream medicine has always heatedly … Read more

Cortisol may drive COVID-19 mortality

The reason I decided to do a post on this study is that over the last several months, various public health authority bodies around the world have adopted “treatment protocols” for COVID-19 hospitalized patients, and virtually all such protocols contain a potent synthetic glucocorticoid such as dexamethasone. If the findings of the study below are … Read more