Low-dose niacinamide has striking anti-obesity effects

It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as ChromaDex to fully “own” that market by … Read more

Hypogonadism in older males due to low OXPHOS

I suspect many readers will simply say “duh!”, but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the actual cause of this decline in androgens in the first place … Read more

Even briefly elevated lactate is a “master” cause of chronic diseases

The title of the post actually does not do justice to how strongly the study authors word their statements in regards to lactate. The lead study author called lactate “a master regulator of carcinogenesis” (with “regulator” being a euphemism for “cause”, otherwise the study won’t get published), while the rest of the study goes to … Read more

Humans have a ‘salamander-like’ ability to regrow cartilage

The title says it all, but the study authors make the unfortunate/handicapped conclusion that while we may very well be able to regrow cartilage, we cannot regrow limbs. Well, multiple animal studies I posted in the last beg to disagree and point to both high metabolism and progesterone as potent regenerative factors that may be … Read more