Long work hours (stress) at the office cause hypertension and CVD

Many of my readers surely are familiar with the saying “work hard, play hard”. This mantra is at the core of the psychotic work culture of most “developed” countries and despite the assurances of doctors and public health officials that bad health is largely due to “bad luck” (e.g. genes) the skyrocketing rates of cardiovascular … Read more Long work hours (stress) at the office cause hypertension and CVD

Serotonin causes anhedonia…and mental illness in general

As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past demonstrating that chronic … Read more Serotonin causes anhedonia…and mental illness in general

Chronic stress (adversity) lowers dopamine and causes mental illness

The evidence for the role of chronic stress in virtually every health condition doctors have a name for just keeps on accumulating. Unfortunately, even in this latest study the scientists keep insisting that there is some mysterious and unquantifiable difference between chronic stress “increasing risk of” and “causing” pathology. Yet, those same scientists have no … Read more Chronic stress (adversity) lowers dopamine and causes mental illness

Energy deficiency due to stress causes anxiety, panic disorders, and subbordination

This is a great study on so many levels. First, it directly demonstrates that chronic stress leads to mitochondrial dysfunction and reduced oxidative phosphorylation. Second, it demonstrates that glucocorticoids (cortisol) are a direct cause of this energy production downregulation. Third, it demonstrates a direct parallel between animal models and human mood/mental disorders by comparing the … Read more Energy deficiency due to stress causes anxiety, panic disorders, and subbordination

Mitochondria (energy) as the main driver of health, intelligence, and aging

We are finally starting to see Peat enter the mainstream and article like the one below are calling for a complete review of what we know about health and aging and how intelligence is tied to them. As the authors says, or actually borrows from Peat, there is solid evidence that mitochondrial function and ATP … Read more Mitochondria (energy) as the main driver of health, intelligence, and aging