Fatty acid oxidation (FAO) inhibition abrogates triple-negative breast cancer

The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with such a … Read more Fatty acid oxidation (FAO) inhibition abrogates triple-negative breast cancer

Cortisol drives triple-negative breast cancer, androgens (DHT) are therapeutic

Another confirmation of a hypothesis made more than 100 years ago – i.e. all cancers are hormonally sensitive and to speak of a steroid-negative cancer is nonsense. If all cancers are driven by at least one steroid then it would make sense to discover what that steroid is and develop therapeutic interventions that block its … Read more Cortisol drives triple-negative breast cancer, androgens (DHT) are therapeutic

DHEA-S completely prevents breast cancer metastasis due to estrogen

A great new study that debunks several myths related to DHEA. One of those myths is that when used in physiological doses DHEA can increase risk of estrogen-positive cancers, especially breast cancer. Another myth is that declining DHEA levels seen with advancing age are simply a consequence of aging and restoring said levels would likely … Read more DHEA-S completely prevents breast cancer metastasis due to estrogen

While estradiol falls, estrone rises with age and is much more relevant for estrogen-driven diseases

I posted a few studies in the past demonstrating that estrone (E1) and especially its long-lasting derivative estrone sulfate (E1S) are reliable biomarkers of both breast and prostate cancer progression/prognosis. However, for some reason the medical industry is obsessed with estradiol and since its levels plummet after menopause this has allowed doctors to declare menopause … Read more While estradiol falls, estrone rises with age and is much more relevant for estrogen-driven diseases