SSRI drugs decrease androgens / progestogens, increase estrogens

As hard as it is to believe, this is the actual title of the study – i.e. SSRI drugs are bonafide endocrine disruptors. As it turns out, all of the six most-prescribed SSRI drugs the study looked at behaved not only as inhibitors of gonadal androgen synthesis (e.g. testosterone, DHT), but also adrenal androgens (DHEA) … Read more

Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and relatives who struggled to conceive, and it is … Read more

DHT is an estrogen (receptor) antagonist

A neat little study, and in-vivo at that, which demonstrates that DHT is a direct estrogen receptor (ER) antagonist. According to the study, so are testosterone, nandrolone and a few other steroids with demonstrated therapeutic effects on ER-positive breast cancer (BC). However, all of the other steroids mentioned by the study are aromatizable and as … Read more

Estrogen may be the cause of “estrogen-negative” breast cancer

IMO, one of the biggest medical frauds so far is the idea that androgens (especially DHT) cause and promote prostate cancer. We now have an abundance of evidence (posted on this blog) that it is instead deficiency of androgens and/or excess of estrogens that initiates and drives the progression of prostate cancer. When chemical castration … Read more

Male sexual function does NOT require estrogen

It is a “sacred” mantra in the medical and sports worlds – i.e. “estrogen is crucial for males, without it they won’t have any sex life”. This mantra is also part of the justification given for the currently ongoing COVID-19 clinical trials with males receiving estrogen in the hope it will reduce the lethality of … Read more

Inhibiting estrogen synthesis may treat / prevent ectopic pregnancy

I just made a post about the role of estrogen in male infertility, which matches perfectly the evidence about estrogen’s role as a metabolic inhibitor, and an agent that causes atrophy in both male and female gonads. Male fertility depends on intensity of (sperm) metabolism Now, a new study demonstrates that using an aromatase inhibitor … Read more

Inhibiting aromatase (to lower estrogen) may treat gastric (stomach) cancer

Yet another study demonstrating the causative link between estrogen and a cancer considered to be hormone-independent. Gastric cancer is one of the leading causes of cancer-deaths worldwide, and especially Asian countries. It is considered very hard to treat and most patients are diagnosed at stages when surgery is not a viable option. As such, the … Read more

Reversing human aging likely possible with progesterone / DHEA

I decided to make a post on this topic after seeing the popular press articles about a study claiming reversal of human biological (as opposed to chronological) aging. That study used human growth hormone (HGH), DHEA and metformin combination as an intervention that restores thymus health and thus reverses immunosenescence (immune system aging). It is … Read more