An estrogen antagonist treats many cancers, including triple-negative breast cancer

Just a portion of the title is already paradoxical, according to mainstream medical dogma. Namely, how can an estrogen antagonist treat triple-negative breast cancer that is supposedly fully immune to any hormonal effects!? Well, maybe the whole idea of hormonal “receptors” as the only mechanism through which hormones exert their effects on cells is rather … Read more

Vitamin A is required for male fertility

I am posting about this study not because I am thrilled at the possibility of society now having oral (non-steroid) contraceptive methods for males, but rather because this study highlights that vitamin A is actually required for male fertility. Even minor interference with so-called retinoic acid receptor alpha (RAR-a) causes fertility problems and fully blocking … Read more

DHT is an estrogen (receptor) antagonist

A neat little study, and in-vivo at that, which demonstrates that DHT is a direct estrogen receptor (ER) antagonist. According to the study, so are testosterone, nandrolone and a few other steroids with demonstrated therapeutic effects on ER-positive breast cancer (BC). However, all of the other steroids mentioned by the study are aromatizable and as … Read more

Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects mainly through activation of the TLR4 receptor, and pregnenolone … Read more