Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a catabolic steroid) is, naturally, a potent inducer of those … Read more Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

PUFA is catabolic, SFA is anti-catabolic (anabolic)

During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT is induced almost exclusively by glucocorticoids and is used clinically as … Read more PUFA is catabolic, SFA is anti-catabolic (anabolic)

Glucose is anabolic for thymus, opposes catabolic effects of cortisol

As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone and even DHT (but not by testosterone). The study below confirms the catabolic effects of cortisol … Read more Glucose is anabolic for thymus, opposes catabolic effects of cortisol

Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration

A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much to the chagrin of the medical industry, the increased dietary … Read more Cholesterol and saturated fat are anabolic; PUFA/MUFA akin to chemical castration