PUFA is catabolic, SFA is anti-catabolic (anabolic)

During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT is induced almost exclusively by glucocorticoids and is used clinically as … Read more PUFA is catabolic, SFA is anti-catabolic (anabolic)

Low energy production (glucose metabolism) may cause andropause

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state “andropause”. Its official name is age-related hypogonadism and most of that hypogonadism is of the “secondary” type – i.e. the gonads appears to be in fine shape but for some “unknown” reason they do … Read more Low energy production (glucose metabolism) may cause andropause

The tetracyclines protect against sepsis independently of their antibiotics effects

A remarkable study, which demonstrates that not all antibiotics have been created equal. Namely, the tetracycline family of antibiotics is strikingly protective against lethality from sepsis, and that protection is completely separate from their antibiotics effects. For example, the study demonstrated that pre-treatment with a puny single dose of doxycycline in a HED of 0.25 … Read more The tetracyclines protect against sepsis independently of their antibiotics effects

The Cure for Aging Might be the Cure for Alzheimer’s

Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure of the other. http://raypeat.com/articles/articles/alzheimers.shtml … Read more The Cure for Aging Might be the Cure for Alzheimer’s

Low, not high, metabolism creates oxidative stress

A hugely popular tenet of the “rate of living” theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental health disorders. However, the explanation of higher ROS … Read more Low, not high, metabolism creates oxidative stress

Lowering estrogen prevents memory decline in menopausal females

As many of my readers know, the WHI studies were highly detrimental to the profits of the estrogen industry. Every since the results of those studies came out, the estrogen industry has been trying to undermine the findings and re-introduce estrogen HRT for women with the claims that estrogen is highly beneficial if used in … Read more Lowering estrogen prevents memory decline in menopausal females

Estrogen can both cause and exacerbate Lupus

A quick post as a response to a recent argument I had over email with an endocrinologist who follows me on Twitter. His claim was that the causes of Lupus are currently unknown but are likely “multifactorial” and me ascribing such causes to “isolated peculiarities” such as endotoxin (LPS) or estrogen is unwarranted. The fact … Read more Estrogen can both cause and exacerbate Lupus

Aspirin has dramatically lower bleeding risk than pharma anticoagulants

Just a quick post that adds to the mountain of evidence contradicting the fearmongering about aspirin we hear on a daily basis from every doctor who manages to get some TV time. It has been known for a while that aspirin lowers bleeding risk in brain and GI tract, despite being an anti-coagulant drug itself. … Read more Aspirin has dramatically lower bleeding risk than pharma anticoagulants

Dietary PUFA in childhood causes diabetes and irreversible (male) infertility

A great study, which corroborates the discussion in another recent post of mine on PUFA’s role in infertility and insulin-resistance / diabetes. However, the study below found that the infertility caused by dietary PUFA exposure were NOT reversible upon discontinuation of the high-fat (both PUFA and MUFA) diet, while previous studies found that the infertility … Read more Dietary PUFA in childhood causes diabetes and irreversible (male) infertility

Alcohol causes liver (and other organ) damage by lowering NAD/NADH ratio

A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the start of the “pandemic” have exacerbated dramatically. As most … Read more Alcohol causes liver (and other organ) damage by lowering NAD/NADH ratio