{"id":925,"date":"2020-03-05T15:33:49","date_gmt":"2020-03-05T20:33:49","guid":{"rendered":"http:\/\/haidut.me\/?p=925"},"modified":"2020-04-16T14:28:38","modified_gmt":"2020-04-16T18:28:38","slug":"vitamin-c-and-immuno-oncology","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=925","title":{"rendered":"Vitamin C and Immuno-Oncology"},"content":{"rendered":"

Just posting this to keep my readers aware that after mocking Linus Pauling for half a century mainstream medicine now seems eager to embrace his therapies of cancer using high-doe vitamin C. Unfortunately, it appears even staff writers at ScienceMag are unaware that therapies with vitamin C have already been proven effective and one of them is now even FDA-approved. Namely, the drug Apatone<\/a>, which I have posted about in the past. Well, slowly but surely medicine will do 180 degree turn.<\/p>\n

https:\/\/blogs.sciencemag.org\/pipeline\/archives\/2020\/03\/02\/vitamin-c-and-immuno-oncology<\/a><\/p>\n

“…Linus Pauling was a fearsomely great scientist who is remembered by the general public for his advocacy of megadoses of Vitamin C, a favorite topic of his later in life. Infectious disease, cancer: Pauling advised gram amounts of ascorbic acid and had a lot of theorizing to offer about why that was beneficial<\/strong>. So while his scientific legacy is (among other things) his work on chemical bonding, on genetically-based disease and the concept of molecular biology in general, and plenty of lesser-known deeds such as encouraging the earliest NMR studies of organic compounds, his legacy in the wider world involves increased vitamin sales and the association of Vitamin C in particular with the treatment of disease.”<\/p>\n

“…Here\u2019s a new paper<\/a> from a team in Italy that suggests that these effects have to do with immuno-oncology, and that the combination of i.v. ascorbate and immunomodulators might be quite useful<\/span><\/strong>. Vitamin C only showed effects in mouse tumor models when the animals had a fully competent immune system<\/strong>. Narrowing down, its beneficial effects appear to depend on T-cell pathways: antibodies to CD4 or CD8, for example, took things back to baseline tumor development. But on the other hand, the combination of Vitamin C with anti-PD1 and\/or anti-CTLA-4 antibodies was noticeably more effective. This appears to be independent of the pro-oxidative damage mechanism mentioned above, as well as of the reported effects of high-dose ascorbate on iron metabolism.”<\/p>\n","protected":false},"excerpt":{"rendered":"

Just posting this to keep my readers aware that after mocking Linus Pauling for half a century…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[1111,1112,55,13,621,1113,53,892],"class_list":["post-925","post","type-post","status-publish","format-standard","hentry","category-science","tag-ascorbate","tag-ascorbic","tag-cancer","tag-effective","tag-immunity","tag-pauling","tag-treat","tag-vitamin-c","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=925"}],"version-history":[{"count":3,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/925\/revisions"}],"predecessor-version":[{"id":1007,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/925\/revisions\/1007"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}