{"id":759,"date":"2019-12-02T17:30:25","date_gmt":"2019-12-02T22:30:25","guid":{"rendered":"http:\/\/haidut.me\/?p=759"},"modified":"2019-12-02T17:30:25","modified_gmt":"2019-12-02T22:30:25","slug":"progesterone-may-treat-diabetes-obesity-and-metabolic-syndrome","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=759","title":{"rendered":"Progesterone may treat diabetes, obesity, and metabolic syndrome"},"content":{"rendered":"<p>Interesting new study, which adds more to the already existing mountain of evidence for the benefit of progesterone in a variety of conditions of metabolic origin. While the study does not mention any specific doses, it is known that the receptor (<a href=\"https:\/\/en.wikipedia.org\/wiki\/PGRMC2\">PGRMC2<\/a>) whose activation the study found to be beneficial for diabetes\/obesity, is activated by progesterone in physiological concentrations. This means that even &#8220;low&#8221; doses of progesterone in the 15mg-30mg daily range should be enough to activate that specific cell-membrane progesterone receptor and replicate the findings of the study. I am not even sure why the study did not use progesterone as the obvious choice of endogenous activator but instead went with an obscure (but patented and expensive) synthetic molecule. Wait, I think I know the reason&#8230;<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1774-2\">https:\/\/www.nature.com\/articles\/s41586-019-1774-2<\/a><\/p>\n<p><a href=\"https:\/\/www.hindustantimes.com\/more-lifestyle\/this-protein-that-appears-to-play-an-important-role-in-obesity-metabolic-disease\/story-DnfHRkfdV1I6G1EPEC2ktO.html\">https:\/\/www.hindustantimes.com\/more-lifestyle\/this-protein-that-appears-to-play-an-important-role-in-obesity-metabolic-disease\/story-DnfHRkfdV1I6G1EPEC2ktO.html<\/a><\/p>\n<p>&#8220;&#8230;Scientists at Scripps Research have come up with <strong>an unexpected finding of a protein that is highly expressed in fat tissue<\/strong>. The\u00a0<a title=\"study\" href=\"https:\/\/www.hindustantimes.com\/more-lifestyle\/yoga-helps-you-sleep-better-reduces-lower-back-pain\/story-BGT1R14ej4rDR6bOtDr9CO.html\">study<\/a> has <strong>opened the door to critical new understandings about obesity, metabolism and potentially other diseases<\/strong>. The results of the\u00a0<a title=\"study\" href=\"https:\/\/www.hindustantimes.com\/more-lifestyle\/try-hot-yoga-for-lower-blood-pressure\/story-yLSs83bzY3H6aMYZ6VbPYP.html\">study<\/a> were published in the Journal Nature. The <strong>signaling protein, known as <span style=\"color: #ff0000;\">progesterone<\/span> receptor membrane component 2 (PGRMC2)<\/strong>, had not been extensively studied in the past. Short for \u201cprogesterone receptor membrane component 2,\u201d it had been detected in the uterus, liver and several areas of the body.&#8221;<\/p>\n<p>&#8220;&#8230;And that is how they made their next big discovery: <strong>Without PGRMC2 present in their fat tissues, mice that were fed a high-fat diet became intolerant to glucose and insensitive to insulin, hallmark symptoms of diabetes and other metabolic diseases<\/strong>. By contrast, <span style=\"color: #ff0000;\"><strong>obese-diabetic mice that were treated with a drug to activate the PGRMC2 function showed a substantial improvement of symptoms associated with diabetes<\/strong><\/span>.&#8221;<\/p>\n<p>&#8220;&#8230;\u201cEven though their brain was sending the right signals to turn on the heat, the mice were unable to defend their body temperature,\u201d Galmozzi says. \u201c<strong>Without heme, you get mitochondrial dysfunction and the cell has no means to burn energy to generate heat<\/strong>.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Interesting new study, which adds more to the already existing mountain of evidence for the benefit of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[285,953,952,97,77,319,951,153,662,53],"class_list":["post-759","post","type-post","status-publish","format-standard","hentry","category-science","tag-diabetes","tag-heat","tag-heme","tag-metabolism","tag-mitochondria","tag-obesity","tag-pgrmc2","tag-progesterone","tag-therapeutic","tag-treat","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=759"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/759\/revisions"}],"predecessor-version":[{"id":760,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/759\/revisions\/760"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}