{"id":480,"date":"2019-08-22T13:50:23","date_gmt":"2019-08-22T17:50:23","guid":{"rendered":"http:\/\/haidut.me\/?p=480"},"modified":"2019-09-27T11:51:24","modified_gmt":"2019-09-27T15:51:24","slug":"estrone-not-estradiol-rises-with-age-and-is-much-more-relevant-for-estrogen-driven-diseases","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=480","title":{"rendered":"While estradiol falls, estrone rises with age and is much more relevant for estrogen-driven diseases"},"content":{"rendered":"

I posted a few studies in the past demonstrating that estrone (E1) and especially its long-lasting derivative estrone sulfate (E1S) are reliable biomarkers of both breast and prostate cancer progression\/prognosis. However, for some reason the medical industry is obsessed with estradiol and since its levels plummet after menopause this has allowed doctors to declare menopause a life-stage characterized by estrogen “deficiency”. E1 and\/or E1S are almost never measured and most endocrinologists do not consider those steroids relevant for health\/disease. While the estrones are indeed weaker estrogens than estradiol, both of them easily convert into estradiol or estriol in tissues and exert tissue-specific effects – a process known as “intracrinology”. If E1 and E1S are measured, together with estriol and estradiol (and preferably prolactin as well), it becomes apparent that total estrogen reserves RISE<\/strong><\/span> with age instead of falling as the doctor claim. Thus, menopause and its associated diseases are driven by estrogen excess and not deficiency.<\/p>\n

Well, the study below may finally change this attitude. It found (unsurprisingly) that estrone is elevated in post-menopausal women and its levels correlated well with age – i.e. the older the woman the higher her estrone levels. It also makes the direct claim that unless estrone is also measured as part of a the hormone panels often done for women, using only estradiol as a diagnostic\/treatment biomarker is next to meaningless.<\/p>\n

https:\/\/www.healio.com\/endocrinology\/reproduction-androgen-disorders\/news\/online\/%7B4f6a53c0-30bd-4a87-9959-64ee05228da6%7D\/higher-testosterone-level-may-confer-survival-advantage-in-older-women<\/a><\/p>\n

“…Researchers found that women aged 80 to 84 years had estrone levels that were on average 9.2% higher vs. women aged 70 to 74 years (P =\u00a0<\/em>.001); women aged at least 85 years had estrone levels that were on average 11.7% higher vs. women aged 70 to 74 years<\/strong> (P =\u00a0<\/em>.01). When stratified by BMI, excess weight further influenced sex steroid levels, <\/strong>the researchers wrote, <\/strong>noting that older women with obesity had estrone levels that were on average 34.1% higher vs. women with normal weight<\/strong> (P <\u00a0<\/em>.001). The increasing proportion of women with unmeasurable [estradiol] in the older groups most likely reflects different effects of age on the enzymatic pathways essential for the biosynthesis of these hormones<\/strong>,\u201d the researchers wrote. \u201cRegardless, a key message <\/strong>from the findings<\/span> is that studies<\/span> investigating the association between estrogens and diseases of aging in postmenopausal women<\/span> must measure [estrone] in order to provide meaningful findings<\/strong><\/span>.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

I posted a few studies in the past demonstrating that estrone (E1) and especially its long-lasting derivative…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[671,672,55,437,62,636,670,669],"class_list":["post-480","post","type-post","status-publish","format-standard","hentry","category-science","tag-biomarker","tag-breast-cancer","tag-cancer","tag-crucial","tag-disease","tag-estrone","tag-important","tag-menopause","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/480","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=480"}],"version-history":[{"count":5,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/480\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/480\/revisions\/602"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}