{"id":3149,"date":"2026-11-15T00:07:33","date_gmt":"2026-11-15T05:07:33","guid":{"rendered":"https:\/\/haidut.me\/?p=3149"},"modified":"2026-11-15T00:07:33","modified_gmt":"2026-11-15T05:07:33","slug":"pufa-metabolites-leukotrienes-drive-scar-tissue-growth-blockade-is-therapeutic","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=3149","title":{"rendered":"PUFA metabolites (leukotrienes) drive scar tissue growth, blockade is therapeutic"},"content":{"rendered":"<p>Once again, PUFA rears its ugly head in health areas traditionally considered not related to fat metabolism at all. Namely, the study below shows that topical application of a lipoxygenase (LOX) inhibitor can prevent the accumulation of scar tissue. Whether LOX inhibition\/blockade can completely prevent scar formation remains to be tested, but I don&#8217;t see a reason why it would not work, especially if the treatment is a combination of local (e.g. topical) and systemic (oral or IV\/injection). Of course, avoidance of dietary PUFA would probably be the best approach, but since it is ubiquitous in the Western diet, LOX inhibition is probably a more practical option. Also, since scar tissue is a form of fibrosis, the study raises the possibility that other forms of fibrosis (e.g. liver, kidneys, heart, etc) would also be preventable\/treatable by LOX inhibition and\/or PUFA avoidance.<\/p>\n<p><a href=\"https:\/\/es.tradingview.com\/news\/smallcaps:b3836b948094b:0-syntara-expands-safety-and-tolerability-study-of-snt-9465-topical-scar-treatment\/\">https:\/\/es.tradingview.com\/news\/smallcaps:b3836b948094b:0-syntara-expands-safety-and-tolerability-study-of-snt-9465-topical-scar-treatment\/<\/a><\/p>\n<p>&#8220;&#8230;Syntara has expanded a Phase 1b study of its next-generation topical <span style=\"text-decoration: underline;\"><strong>anti-fibrotic drug candidate SNT-9465 developed to improve the structure and appearance of hypertrophic sternotomy scars<\/strong><\/span>.&#8221;<\/p>\n<p>&#8220;&#8230;Although there are differences in aetiology and location of the scars between the studies (burns vs surgical), it is anticipated that <span style=\"text-decoration: underline;\"><strong><span style=\"color: #ff0000; text-decoration: underline;\">higher LOX levels may drive faster tissue turnover within the scar<\/span>, creating a greater opportunity for a pan-LOX inhibitor such as SNT-9465 to remodel scar architecture<\/strong><\/span>. \u201cHypertrophic scarring remains an area of significant unmet need and we look forward to evaluating whether the biological rationale for pan-LOX inhibition translates into an acceptable safety and tolerability profile for patients,\u201d Mr Phillips said.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Once again, PUFA rears its ugly head in health areas traditionally considered not related to fat metabolism&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2124,64,12,1636,393,159,1877],"class_list":["post-3149","post","type-post","status-publish","format-standard","hentry","category-science","tag-collagen","tag-fibrosis","tag-inflammation","tag-leukotriene","tag-lox","tag-pufa","tag-scar","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/3149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3149"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/3149\/revisions"}],"predecessor-version":[{"id":3150,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/3149\/revisions\/3150"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}