https:\/\/medicaldialogues.in\/orthopaedics\/news\/emerging-evidence-highlights-vitamin-es-role-across-multiple-orthopaedic-conditions-study-160271<\/a><\/p>\n“…The key findings of the study were:<\/p>\n
\u2022 19 manuscripts were selected for the review. Vitamin E is utilised in diverse forms in orthopaedic patients: administered systemically, intraarticularly or locally.<\/p>\n
\u2022 Systemically-administered vitamin E can mitigate osteoarthritis progression through strengthening of adjoining musculature, gene regulation, protection of subchondral vasculature, and anti-inflammatory properties.<\/p>\n
\u2022 Vitamin E incorporation has been demonstrated to improve the wear characteristics of highly crosslinked polyethylene and metal alloys in arthroplasty through its antioxidant and osteointegrative abilities.<\/p>\n
\u2022 Antioxidant vitamin E has been shown to mitigate postoperative arthrofibrosis and septic loosening. Vitamin E can positively influence late callus formation during secondary fracture healing.<\/p>\n
\u2022 Through its effects on osteoblastic cells, proinflammatory cytokines, growth factors, antioxidant mechanism, hormones and micro-RNA, systemic vitamin E administration can meliorate osteoporosis and mitigate fractures.<\/p>\n
The authors concluded – \u201cThere is emerging evidence regarding the promising roles of vitamin E in diverse orthopaedic conditions such as osteoarthritis, osteoporosis, fracture healing, osteomyelitis and arthroplasty<\/strong><\/span>. These actions of vitamin E are attributed to its antioxidant, anti-infl ammatory and immunomodulatory functions<\/strong><\/span>. Large-scale clinical trials are needed to ascertain its safety, effective administrative dosage and future prospects in the realm of orthopaedic surgery.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"This was a meta-study, so a single optimal dose for all mentioned conditions is probably not known…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[632,2186,2018,2187,287,760,758],"class_list":["post-2966","post","type-post","status-publish","format-standard","hentry","category-science","tag-estrogen","tag-fractures","tag-osteoarthritis","tag-osteomyelitis","tag-osteoporosis","tag-tocopherol","tag-vitamin-e","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2966"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2966\/revisions"}],"predecessor-version":[{"id":2967,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2966\/revisions\/2967"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}