{"id":2929,"date":"2025-11-25T15:52:46","date_gmt":"2025-11-25T20:52:46","guid":{"rendered":"https:\/\/haidut.me\/?p=2929"},"modified":"2025-11-25T15:52:46","modified_gmt":"2025-11-25T20:52:46","slug":"mictochondrial-nad-levels-drive-liver-regeneration","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=2929","title":{"rendered":"Mictochondrial NAD+ levels drive liver regeneration"},"content":{"rendered":"<p>Given the prevalence of liver disease &#8211; NAFLD, NASH, cirrhosis and even liver cancer &#8211; in the general population, I think the study findings below would be well-received. Especially, considering the implications of being able to treat most kinds of liver disease with something as simple as niacinamide (an NAD+ precursor), with likely synergistic effects when combined with an oxidizing agent (which increases oxidation of NADH back into NAD+) such as emodin, vitamin K, thymoquinone, methylene blue, tetracycline antibiotics, etc. I can&#8217;t get the full text of the study yet, as the study was just published, but once it becomes available I will modify the post to contain the oral supplementation protocol with NAD+ precursor(s) that the study mentions.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-025-25496-1\">https:\/\/www.nature.com\/articles\/s41598-025-25496-1<\/a><\/p>\n<p>&#8220;&#8230;We show that the size of the mitochondrial NAD+ pool in hepatocytes is regulated by SLC25A51 expression in vivo. We further find that selectively <span style=\"text-decoration: underline;\"><strong>increasing mitochondrial NAD+ is sufficient to improve liver regeneration after partial hepatectomy, equivalent to the effect of systemic high-dose NAD+ precursor supplementation<\/strong><\/span>.&#8221;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Given the prevalence of liver disease &#8211; NAFLD, NASH, cirrhosis and even liver cancer &#8211; in the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[65,1256,61,77,70,59,60,1018],"class_list":["post-2929","post","type-post","status-publish","format-standard","hentry","category-science","tag-cirrhosis","tag-hepatic","tag-liver","tag-mitochondria","tag-nad","tag-nafld","tag-nash","tag-regeneration","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2929"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2929\/revisions"}],"predecessor-version":[{"id":2930,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2929\/revisions\/2930"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}