{"id":2844,"date":"2025-09-17T16:34:32","date_gmt":"2025-09-17T20:34:32","guid":{"rendered":"https:\/\/haidut.me\/?p=2844"},"modified":"2025-09-17T16:34:32","modified_gmt":"2025-09-17T20:34:32","slug":"daily-low-dose-aspirin-halves-diabetes-incidence","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=2844","title":{"rendered":"Daily low-dose aspirin halves diabetes incidence"},"content":{"rendered":"<p>The commercials on TV are filled with all kinds of drugs targeting (pre)diabetes, obesity and insulin resistance. All such drugs invariably come with a long list of very serious, even deadly, side effects and mainstream medicine is not a step closer to preventing or curing diabetes than it was 50 years ago. Sugar continues to be demonized, while low-carb diets and fasting are all the rage now and have been for the last 10-15 years. None of the drugs on the market for preventing diabetes can boast more than single-digit risk reduction of diabetes, and pharma companies still consider such results a monumental &#8220;success&#8221;. Well, it looks like humble aspirin, even at the low-dose (100mg daily) commonly prescribed for cardiovascular issues, can reduce the incidence of diabetes by about 50%. It is a shame the study did not examine the effects of higher aspirin doses, as aspirin&#8217;s pro-metabolic effects are known to be dose-dependent. We can thank Big Pharma and the public health authorities for that study handicap given their relentless fearmongering about aspirin &#8220;risks&#8221; and how it should be used only if a doctor prescribes it and only if other options are not available. Now, the study did find a small increase in bleeding risk with aspirin, but paradoxically this rusk is actually more pronounced at lower aspirin doses than at higher ones. Thus, a higher dose in the range of, say, 300mg-500mg would probably have an even stronger anti-diabetic effect while reducing bleeding risks.<\/p>\n<p><a href=\"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-025-02802-9\">https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-025-02802-9<\/a><\/p>\n<p>&#8220;&#8230;The primary outcome was the onset of T2DM, defined as a new diagnosis accompanied by antidiabetic prescriptions lasting more than 30\u00a0days. Gastrointestinal bleeding was assessed as the safety endpoint. Over the follow-up period, 488 new cases of T2DM were documented (15.6% of the total population), with 174 cases occurring in the aspirin group (22.3 per 1000 person-years) and 314 in the non-aspirin group (40.2 per 1000 person-years), indicating a significantly lower incidence of diabetes among aspirin-treated individuals. Given the difference in comorbidity rates between groups, a Cox regression analysis was conducted across the entire follow-up period, showing that aspirin use was associated with a 47% reduction in the risk of developing T2DM (HR 0.53, 95% CI 0.44\u20130.64,\u00a0<i>p<\/i>\u2009&lt;\u20090.001). However, aspirin use was also linked to an increased risk of gastrointestinal bleeding (4.9% vs 3.1%,\u00a0<i>p<\/i>\u2009&lt;\u20090.05). Kaplan\u2013Meier survival curves confirmed a significantly lower cumulative incidence of T2DM in the aspirin-treated group (log-rank test\u00a0<i>p<\/i>\u2009&lt;\u20090.0001)&#8230;.<span style=\"text-decoration: underline;\"><strong>Daily treatment with 100\u00a0mg aspirin was associated with approximately a 50% reduction in the incidence of new-onset T2DM<\/strong><\/span>, but also with an increased risk of gastrointestinal bleeding, in elderly individuals with prediabetes.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The commercials on TV are filled with all kinds of drugs targeting (pre)diabetes, obesity and insulin resistance&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[326,1162,285,281,1060,1058,665],"class_list":["post-2844","post","type-post","status-publish","format-standard","hentry","category-science","tag-aspirin","tag-diabesity","tag-diabetes","tag-insulin-resistance","tag-low-dose","tag-prediabetes","tag-t2dm","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2844"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2844\/revisions"}],"predecessor-version":[{"id":2845,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2844\/revisions\/2845"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}