{"id":2787,"date":"2025-05-16T16:02:17","date_gmt":"2025-05-16T20:02:17","guid":{"rendered":"https:\/\/haidut.me\/?p=2787"},"modified":"2025-05-16T16:02:17","modified_gmt":"2025-05-16T20:02:17","slug":"anti-depressant-drugs-ssri-cause-heart-defects-disease-by-inhibiting-oxidative-metabolism","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=2787","title":{"rendered":"Anti-depressant drugs (SSRI) cause heart defects\/disease by inhibiting oxidative metabolism"},"content":{"rendered":"<p>I am amazed by the number of already published studies that openly admit that SSRI drugs have a well-known and wide range of organ-specific toxicities, especially when prescribed to pregnant women. Yet, despite this abundance of evidence, psychiatry still continues to claim that the &#8220;benefits&#8221; of those drugs outweigh the risks, even in the face to skyrocketing rates of childhood disease thought to begin in-utero, including autism, cardiac defects, muscular dystrophies, bone deformities, neurological conditions, etc. Be that as it may, the study below suggests a common mechanism behind the wide range of SSRI toxicities, and apparently it (again!) comes down to metabolism. Serotonin (5-HT) is one of the master (negative) regulators of oxidative phosphorylation, so it is quite logical to observe the negative metabolic effects on the heart that the study discovered. Now, if SSRI\/serotonin can have such profound negative effects on the heart\u00a0 &#8211; an organ that is quite resilient to damage due to the high concentrations of protective steroids (e.g. testosterone, DHT and pregnenolone, etc) in it &#8211; imagine what SSRI\/serotonin can do to the organ that is the most sensitive to energetic disturbances &#8211; the brain.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s42003-025-08168-8\">https:\/\/www.nature.com\/articles\/s42003-025-08168-8<\/a><\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline;\"><strong>The administration of selective serotonin reuptake inhibitors (SSRIs) during pregnancy can increase the odds of congenital heart defects in babies<\/strong><\/span>. The present study aims to explore the toxic effects of SSRIs on the cardiac systems and the underlying mechanism. We apply human pluripotent stem cells to establish 2D-monolayer cardiomyocyte and 3D-cardiac organoid models to evaluate the <span style=\"text-decoration: underline;\"><strong>effects of three SSRIs (fluoxetine, paroxetine, and sertraline)<\/strong><\/span> on cardiac development. We observe that <span style=\"text-decoration: underline;\"><strong><span style=\"color: #ff0000; text-decoration: underline;\">SSRIs exposure inhibited ATP production and mitochondrial respiration and disrupted mitochondrial homeostasis<\/span> and sarcomere structure in the differentiating cardiomyocytes, presenting high risks of dysfunction and abnormality of cardiomyocytes<\/strong><\/span>. Further analyses in the cardiac organoid model show that <span style=\"text-decoration: underline; color: #ff0000;\"><strong>SSRIs not only reduce mitochondrial respiration and ATP production, but may also affect cardiac development and angiogenesis<\/strong><\/span>. Altogether, our study reveals that SSRIs induce mitochondrial dysfunction and sarcomeric disorganization in cardiomyocytes, implying their potential risk to the cardiac system.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I am amazed by the number of already published studies that openly admit that SSRI drugs have&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[192,99,72,77,2108,883,47,191],"class_list":["post-2787","post","type-post","status-publish","format-standard","hentry","category-science","tag-5-ht","tag-atp","tag-heart","tag-mitochondria","tag-myocytes","tag-oxphos","tag-serotonin","tag-ssri","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2787"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2787\/revisions"}],"predecessor-version":[{"id":2788,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2787\/revisions\/2788"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}