This is one of the few studies that I have seen pointing directly at elevated endotoxin\/LPS as a direct cause of Alzheimer Disease (AD). Just as importantly, the study suggests that eating sufficient amounts of insoluble fiber may be a viable approach to preventing\/treating AD due to the known effect of said fiber in reducing both endotoxin\/LPS production as well as its absorption into the blood from the gut. While the study did not mention it directly, other approaches to lowering the endotoxin\/LPS burden such as activated charcoal or antibiotics, may also be viable approached to AD, with the added convenience of increased portability and very long shelf-life. Still, the naturalness of eating foods high in insoluble fiber such as a carrot salad (which Ray himself recommended widely, and recently even became viral on social media), as well as the added health benefits of foods such as carrots, probably make that a primary option\/approach for most people.<\/p>\n
https:\/\/doi.org\/10.3389\/fneur.2022.900048<\/a><\/p>\n https:\/\/www.thebrighterside.news\/health\/major-new-study-finds-gut-health-is-critical-to-the-prevention-and-cure-of-alzheimers-disease\/<\/a><\/p>\n “…At the heart of the discovery is a molecule teeming with a virulent microbial-generated neurotoxin<\/strong><\/span>. Named lipopolysaccharide (LPS)<\/span> and sourced from the Gram-negative bacteria<\/strong><\/span> Bacteroides fragilis found in our gastrointestinal (GI) tract<\/a>, the specific neurotoxin in question is identified as BF-LPS<\/span><\/strong><\/span>. Dr. Lukiw expounds, \u201cLPSs<\/strong><\/span>, in a broader sense, <\/span>rank amongst the most potent microbial-derived pro-inflammatory neurotoxic glycolipids we know of<\/strong><\/span>.\u201d He continues, \u201cVarious laboratories around the globe, ours included, have pinpointed diverse LPS variants within neurons in the brains affected by Alzheimer\u2019s<\/a><\/strong><\/span>.\u201d To elucidate, the research meticulously maps out the journey of BF-LPS from the gut to the brain and its subsequent effects. The pathway is as follows: BF-LPS seeps out of the GI tract, bypasses the<\/span> blood-brain barrier<\/a>\u00a0using the circulatory system, and then infiltrates various brain compartments<\/strong>.”<\/p>\n “…Its presence there induces inflammation within the brain cells and hinders the neurofilament light (NF-L)<\/strong><\/span> \u2014 a crucial protein that maintains cell stability. A depletion in NF-L can cause severe neuronal cell atrophy, resulting in<\/span> eventual cell death<\/a>, a phenomenon prominently seen in AD<\/strong>-affected neurons. However, all is not lost. The research also uncovers a glimmer of hope \u2014 the entire process can be potentially thwarted with sufficient dietary fiber intake<\/strong><\/span>. What sets this discovery apart are its three innovative aspects. Firstly, the AD-triggering pathway originates within our own bodies, specifically in our GI-tract microbiome<\/a>, making it active and inherent throughout our existence. Secondly, the perilous neurotoxin, BF-LPS, is an organic outcome of our GI-tract’s microbial metabolic processes<\/strong><\/span>. Lastly, controlling the abundance<\/strong><\/span> of Bacteroides fragilis in our microbiome, the neurotoxin’s primary source, is achievable through our fiber intake<\/strong><\/span>. Lukiw simplifies this: \u201cFrom a dietary standpoint, balancing the microbial inhabitants of our\u00a0microbiome<\/a> can effectively regulate AD<\/strong><\/span>-related microbes and their potential to release neurotoxins like BF-LPS.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":" This is one of the few studies that I have seen pointing directly at elevated endotoxin\/LPS as…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[729,2105,119,9,1783,12,10,106],"class_list":["post-2781","post","type-post","status-publish","format-standard","hentry","category-science","tag-alzheimer","tag-carrot","tag-dementia","tag-endotoxin","tag-fiber","tag-inflammation","tag-lps","tag-microbiome","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2781"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2781\/revisions"}],"predecessor-version":[{"id":2782,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2781\/revisions\/2782"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}