{"id":2502,"date":"2024-02-29T13:28:08","date_gmt":"2024-02-29T18:28:08","guid":{"rendered":"http:\/\/haidut.me\/?p=2502"},"modified":"2024-05-04T14:06:13","modified_gmt":"2024-05-04T18:06:13","slug":"the-pro-metabolic-drug-dnp-banned-by-fda-may-treat-most-diseases","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=2502","title":{"rendered":"The pro-metabolic drug DNP, banned by FDA, may treat most diseases"},"content":{"rendered":"

The chemical 2,4-dinitrophenol (DNP)<\/a> is one of the oldest (and most successful) weight loss drugs. It works by not only increasing respiration but also by uncoupling the reactions in the electron transport chain from ATP generation, so that a higher proportion of the energy we get from food is released as heat. In other words, DNP drastically increases thermogenesis (and metabolic rate\/speed), which allows a significant portion of food to be “wasted” as heat instead of stored in the body (mostly as fat). Thus, DNP can not only prevent the weight gain from an obesogenic diet, but also induce weight loss in an already obese person. These effects made DNP a very popular remedy for weight loss in the first half of the 20th century. However, due to a few deaths as a result of heat strokes caused by overdosing DNP, the FDA stepped in and banned the sales and personal use of DNP in the US. To this day, people get aggressively prosecuted if they attempt to sell DNP online or give it to friends\/family. Interestingly, the FDA does not seem to be as strict when it comes to pharma companies toying with such “poison”. Despite the ongoing fearmongering that DNP is “deadly”, behind the scenes multiple pharma companies are running clinical trials with DNP for quite a few serious and truly deadly conditions. In order to limit the fallout with the public due to the double-standard, DNP is no longer called DNP in clinical trials since it has now been patented (naive me thought generic compounds in the public domain are unpatentable), as the pro-mitochondrial drug MP-101 (and its close analog MP-201). A quick look at the list of trials with MP-101 shows that pharma companies are banking on MP-101 treating a wide variety of serious chronic issues including multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington Diasease (HD), Alzheimer Disease (AD), mental illness, obesity, diabetes, immunodeficiency, congenital disorders, etc (see first two links below). In other words, pretty much all major chronic conditions known to medicine. I guess the good news in this entire charade is that if FDA and pharma companies believe DNP….errr..I mean MP-101….can treat all of these conditions then this is an open admission by those entities that all such diseases are metabolic in origin, since DNP…errr…I mean MP-101…has no known mechanism of action other than its uncoupling\/pro-metabolic effects. The bad news is that perhaps millions of people worldwide will get poisoned by the newest pharma fad for weight loss known as GLP-1 agonists (Ozempic, anyone?) before the public wisens up to the fact that there are safer, and truly beneficial pharmacological alternative (e.g. uncouplers) for losing weight. Now, since DNP usage does have risks due to its potency as a thermogenic compound, and it is highly illegal to use therapeutically (unless you are a pharma company, rubbing shoulders with the FDA), one could approximate its effects with other uncouplers such as aspirin, caffeine, progesterone, salt, flavones\/flavanones, etc.<\/p>\n

https:\/\/adisinsight.springer.com\/drugs\/800050437<\/a><\/p>\n

https:\/\/synapse.patsnap.com\/drug\/7efa6f9581334bb3b18623859ad7835d<\/a><\/p>\n

https:\/\/www.streetinsider.com\/Business+Wire\/European+Medicines+Agency+%28EMA%29+Greenlights+Mitochon+Pharmaceuticals+to+Initiate+Phase+IIIa+Biomarker+Study+in+Neurodegenerative+Diseases\/22612238.html<\/a><\/p>\n

EU agency OKs study of therapy to improve mitochondrial function<\/a><\/p><\/blockquote>\n