{"id":2254,"date":"2023-05-26T11:11:19","date_gmt":"2023-05-26T15:11:19","guid":{"rendered":"http:\/\/haidut.me\/?p=2254"},"modified":"2023-05-26T11:15:46","modified_gmt":"2023-05-26T15:15:46","slug":"study-glycine-may-treat-depression-media-glycine-may-cause-depression","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=2254","title":{"rendered":"STUDY: Glycine may treat depression; MEDIA: Glycine may cause depression"},"content":{"rendered":"<p>The level of misreporting in mainstream media is reaching criminal levels. For example, there have been many studies discovering that an increase in the activity of the serotonin transporter (SERT), which results in lower levels of extracellular serotonin, results in alleviation of depression or resilience to its onset. In other words, LOW (extracellular) serotonin is therapeutic for depression. Invariably, the media took those studies and reported &#8220;High serotonin good for depression&#8221;, so basically the exact opposite of what the studies said. It looks like this charade is not isolated to serotonin (and estrogen), but is probably a general rule that media follows at the orders of its pharma sponsors. Case in point &#8211; the study below. It demonstrated that the activation of a specific receptor contributes to the development of depression, and animals lacking that receptor were remarkably resilient to developing depression. Ergo, a substance that inhibits said receptor would be therapeutic for depression. The amino acid glycine was found to be an inhibitor of that receptor and as such is expected to be therapeutic for depression, as well as anxiety and other mood disorders. The study authors even started a company developing synthetic inhibitors of said receptor as treatment for various mental disorders, and another article quoted the study author saying that the reason they are not pursuing glycine (or taurine) as antidepressant treatment is the lack of &#8220;selectivity&#8221; of those molecules for the receptor in question (<a href=\"https:\/\/en.wikipedia.org\/wiki\/GPR158\">GPR158<\/a>). What did mainstream media report? You guess it &#8211; &#8220;<em>glycine&#8230;likely contributing to major depression, anxiety and other mood disorders<\/em>&#8220;. I think we are in a desperate need for a change in the laws protecting media for misleading the public on important health matters. While most people saw clearly the media failure in properly informing the public during the pandemic, the pandemic misdeeds of media are small peanuts compared to issues like the one discussed in this post since the latter affect the health of hundreds of millions of people around the world <span style=\"text-decoration: underline;\"><strong>for decades<\/strong><\/span>, considering mental disorders are typically chronic conditions. Deliberately misreporting on such issues of public health should have legal repercussions. A doctor can lose his\/her license for engaging in such misinformation repeatedly, even if the acts were not deliberate. Why should the media be treated any differently? Oh, and lest I forget, the receptor GPR158 that glycine (and possibly taurine) are inhibiting is <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29419376\/\">activated by glucocorticoids<\/a> and, once activated, also drives the development of various tumors such as prostate cancer. Yet another piece of evidence that stress can directly cause cancer, depression and other mental disorders. Conversely, glycine and taurine can be viewed as functional antagonists to stress\/cortisol.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36996198\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36996198\/<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedaily.com\/releases\/2023\/03\/230330172127.htm\">https:\/\/www.sciencedaily.com\/releases\/2023\/03\/230330172127.htm<\/a><\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"gXCHDEJ0YJ\"><p><a href=\"https:\/\/neurosciencenews.com\/major-depression-glycine-22905\/\">Newly Discovered Trigger for Major Depression Opens New Possibilities for Treatments<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Newly Discovered Trigger for Major Depression Opens New Possibilities for Treatments&#8221; &#8212; Neuroscience News\" src=\"https:\/\/neurosciencenews.com\/major-depression-glycine-22905\/embed\/#?secret=wxQRGRDGF3#?secret=gXCHDEJ0YJ\" data-secret=\"gXCHDEJ0YJ\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline;\"><strong>A common amino acid, glycine, can deliver a \u201cslow-down\u201d signal to the brain, likely contributing to major depression, anxiety and other mood disorders<\/strong><\/span> in some people, scientists at the Wertheim UF Scripps Institute for Biomedical Innovation &amp; Technology have found.&#8221;<\/p>\n<p>&#8220;&#8230;In 2018 the Martemyanov team found the new receptor was involved in stress-induced depression. <span style=\"text-decoration: underline; color: #ff0000;\"><strong>If mice lacked the gene for the receptor, called GPR158, they proved surprisingly resilient to chronic stress<\/strong><\/span>. That offered strong evidence that GPR158 could be therapeutic target, he said. But what sent the signal? A breakthrough came in 2021, when his team solved the structure of GPR158. What they saw surprised them. The GPR158 receptor looked like a microscopic clamp with a compartment \u2014 akin to something they had seen in bacteria, not human cells. \u201cWe were barking up the completely wrong tree before we saw the structure,\u201d Martemyanov said. \u201cWe said, \u2018<span style=\"text-decoration: underline;\"><strong>Wow, that\u2019s an amino acid receptor<\/strong><\/span>. There are only 20, so we screened them right away and <span style=\"text-decoration: underline;\"><strong>only one fit perfectly. That was it. It was <span style=\"color: #ff0000; text-decoration: underline;\">glycine<\/span><\/strong><\/span>.\u201d That wasn\u2019t the only odd thing. <span style=\"text-decoration: underline; color: #ff0000;\"><strong>The signaling molecule was not an activator in the cells, but an inhibitor<\/strong><\/span>. The business end of <span style=\"text-decoration: underline;\"><strong>GPR158 connected to a partnering molecule that hit the brakes rather than the accelerator when bound to glycine<\/strong><\/span>.&#8221;<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"iNBtjZz4HV\"><p><a href=\"https:\/\/www.drugdiscoverytrends.com\/study-suggests-mglyr-could-be-a-promising-antidepressant-target\/\">Study suggests mGlyR could be a promising antidepressant target<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Study suggests mGlyR could be a promising antidepressant target&#8221; &#8212; Drug Discovery and Development\" src=\"https:\/\/www.drugdiscoverytrends.com\/study-suggests-mglyr-could-be-a-promising-antidepressant-target\/embed\/#?secret=7hRmtbsTrF#?secret=iNBtjZz4HV\" data-secret=\"iNBtjZz4HV\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline;\"><strong>Both glycine and aurine affect mGlyR. Researchers believe these chemicals play a role in depression<\/strong><\/span>. \u201cWe have previously published research implicating GPR158 in the pathology of mood disorders,\u201d said\u00a0Kirill Martemyanov, professor and chair of the department of neuroscience at Scripps Biomedical Research. \u201cSpecifically, we found it to be upregulated in humans suffering from major depressive disorder and in mice subjected to stress, which is a major aggravating factor for depression.\u201d<\/p>\n<p>A 1995 study in\u00a0<em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8775762\/\">European Neuropsychopharmacology<\/a><\/em>\u00a0found that glycine and taurine and other excitatory amino acids are dysregulated in the plasma of humans diagnosed with major depressive disorder. Additionally, a 2017 paper in\u00a0<em><a href=\"https:\/\/www.nature.com\/articles\/s41598-017-05051-3\">Nature<\/a><\/em>\u00a0found that <span style=\"text-decoration: underline; color: #ff0000;\"><strong>taurine has an antidepressant effect on stress-induced depressive rats<\/strong><\/span>.<\/p>\n<p>\u201cWe also found that in mice, <span style=\"text-decoration: underline;\"><strong>suppressing GPR158 leads to an antidepressant phenotype and resilience to stress<\/strong><\/span>,\u201d Martemyanov said. \u201cTherefore, we think that interventions aimed at blocking GPR158 would offer relief from stress-induced depression.\u201d<\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline; color: #000000;\"><strong>The widespread presence of <span style=\"color: #ff0000; text-decoration: underline;\">glycine and taurine<\/span>, and their involvement in numerous bodily processes, limit their potential as medications<\/strong><\/span>. The authors note, however, that the identification of mGlyR offers a novel antidepressant target for developing new medications. The authors suspect that such novel drugs would be small molecules that specifically inhibit the mGlyR receptor, as they could prevent potential interactions with related receptors such as GPR179 found in the eye.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The level of misreporting in mainstream media is reaching criminal levels. For example, there have been many&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[81,55,20,44,564,1902,27,933],"class_list":["post-2254","post","type-post","status-publish","format-standard","hentry","category-science","tag-anxiety","tag-cancer","tag-cortisol","tag-depression","tag-glycine","tag-gpr158","tag-stress","tag-taurine","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2254"}],"version-history":[{"count":2,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2254\/revisions"}],"predecessor-version":[{"id":2256,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2254\/revisions\/2256"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}