{"id":2149,"date":"2023-02-22T13:23:58","date_gmt":"2023-02-22T18:23:58","guid":{"rendered":"http:\/\/haidut.me\/?p=2149"},"modified":"2023-02-22T13:23:58","modified_gmt":"2023-02-22T18:23:58","slug":"atherosclerosis-linked-to-high-estrogen-cortisol-serotonin-low-androgens","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=2149","title":{"rendered":"Atherosclerosis linked to high estrogen\/cortisol\/serotonin, low androgens"},"content":{"rendered":"<p>The findings of the study are not surprising, but I wanted to post it on the blog since it is one of the few studies I have seen that examined more than one of the &#8220;sickness&#8221; mediator levels in a major chronic conditions such as cardiovascular disease (CVD), and found <span style=\"text-decoration: underline;\"><strong>all<\/strong><\/span> of them to be elevated. Given the ability of pregnenolone\/progesterone to oppose most of these mediators, and the proven ability of non-aromatizable androgens such as DHT to oppose all of them, one might think that there is nothing mysterious about CVD &#8211; i.e. just another endocrine disorder &#8211; and that its treatment may be quite simple.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6620818\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/6620818\/<\/a><\/p>\n<p>&#8220;&#8230;A comparative study of the heart phasic pattern was carried out using phlebo-, sphygmo- and kinetocardiography in male patients with chronic nonspecific pulmonary disease and the chronic pulmonary heart syndrome with or without atherosclerosis. Systolic pressure in the pulmonary artery was calculated using Burstin&#8217;s method. <span style=\"text-decoration: underline;\"><strong>Atherosclerosis<\/strong><\/span> in patients with chronic nonspecific pulmonary disease <span style=\"text-decoration: underline;\"><strong>was shown to be accompanied by<\/strong><\/span> high pulmonary hypertension and feature <span style=\"text-decoration: underline;\"><strong>corticosteronemia, hyperestrogenemia, androgen (testosterone) deficiency and increased production of serotonin and noradrenalin<\/strong><\/span>.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The findings of the study are not surprising, but I wanted to post it on the blog&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[192,1860,20,166,632,231,1861,47],"class_list":["post-2149","post","type-post","status-publish","format-standard","hentry","category-science","tag-5-ht","tag-atherosclerosis","tag-cortisol","tag-cvd","tag-estrogen","tag-hypogonadism","tag-pulmonary-disease","tag-serotonin","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2149"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2149\/revisions"}],"predecessor-version":[{"id":2150,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/2149\/revisions\/2150"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}