The study shows that a daily dose of 4,000 IU – 8,000 IU vitamin D reduces cancer progression by up to 36%. The study had 2 phases, the first one used 4,000 IU vitamin D daily and the second one used 8,000 IU daily. Both phases reported robust benefits, and also noted something Peat has been mentioning to people over email – overweight\/obese people have trouble raising serum vitamin D levels even when taking large doses. So, for those people a daily dose in the 8,000 IU – 10,000 IU range may be needed. Another study linked below looked at the effects of vitamin D on all types of GI cancers and also found benefit from doses as low as 2,000 IU daily, with higher doses being more beneficial.<\/p>\r\n\r\n\r\n\r\n
https:\/\/www.medpagetoday.com\/hematologyoncology\/coloncancer\/79139<\/a><\/p>\r\n\r\n\r\n\r\n https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2017.35.15_suppl.3506<\/a><\/p>\r\n https:\/\/news.harvard.edu\/gazette\/story\/2019\/04\/high-dose-vitamin-d-shows-benefit-in-patients-with-advanced-colorectal-cancer\/<\/a><\/p>\r\n\r\n\r\n\r\n “…Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease<\/strong>, say scientists from Harvard-affiliated Dana-Farber Cancer Institute<\/a>. Prompted by the \u201cvery encouraging\u201d results of the <\/strong>Sunshine clinical trial<\/strong><\/a>, the potential benefits of vitamin D supplementation in metastatic colorectal cancer will be evaluated in a larger clinical trial planned to open at several hundred sites across the U.S. later this year, said\u00a0Kimmie Ng<\/a>,\u00a0director of clinical research in\u00a0Dana-Farber\u2019s Gastrointestinal Cancer Center<\/a>, and corresponding author of the Sunshine study. \u201cTo our knowledge, this study is the first completed randomized clinical trial of vitamin D supplementation for treatment of advanced or metastatic colorectal cancer,\u201d Ng said. In the high-dose group, patients had a median delay of 13 months before their disease worsened; in the low-dose group, the median delay was 11 months. In addition, patients in the high-dose vitamin D group were 36 percent less likely to have disease progression or death during the follow-up period of 22.9 months<\/strong>. The trial included too few patients to determine whether those who took high-dose vitamin D survived longer overall. \u201cThe results of our trial suggest an improved outcome for patients who received vitamin D supplementation, and we look forward to launching a larger trial to confirm these exciting and provocative findings,\u201d said Charles Fuchs, formerly of Dana-Farber and now director of Yale Cancer Center, the senior author of the study.”<\/p>\r\n\r\n\r\n\r\n “… The Sunshine trial randomized 139 patients with previously untreated metastatic colorectal cancer. One group took pills containing 4,000 international units (IU) of vitamin D per day along with standard chemotherapy, while the other group took 400 units<\/strong> (about the dose found in a multivitamin) along with chemotherapy. “<\/p>\r\n\r\n\r\n\r\n “… Against this backdrop, the randomized, prospective phase 2 Sunshine trial recruited patients at 11 academic and community centers across the U.S. to test whether vitamin D supplementation can improve outcomes in patients with metastatic colorectal cancer. All patients received standard chemotherapy. Patients in the high-dose vitamin D group initially took 8,000 IU a day for 14 days, then 4,000 IU a day thereafter. The low or standard-dose vitamin D group took 400 IU daily<\/strong> during all cycles. All patients were asked not to take any other vitamin D or calcium supplements during the trial period. “<\/p>\r\n\r\n\r\n\r\n “…Analysis of the results showed less benefit from high-dose vitamin D in patients who were obese<\/strong>, and those whose tumors contained a mutated KRAS\u00a0<\/em>gene, suggesting \u201cthat certain subsets of patients may need even higher doses of vitamin D for anti-tumor activity,\u201d the researchers said. They cautioned, however, that high doses of vitamin D shouldn\u2019t be taken except within the context of a clinical trial.”<\/p>\r\n","protected":false},"excerpt":{"rendered":" The study shows that a daily dose of 4,000 IU – 8,000 IU vitamin D reduces cancer…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[54,51,55,50,56,57,58,52,53,49],"class_list":["post-19","post","type-post","status-publish","format-standard","hentry","category-science","tag-advanced","tag-benefit","tag-cancer","tag-cholecalciferol","tag-colon","tag-gastric","tag-gi","tag-prevent","tag-treat","tag-vitamin-d","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/19","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19"}],"version-history":[{"count":5,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/19\/revisions"}],"predecessor-version":[{"id":624,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/19\/revisions\/624"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}