{"id":1808,"date":"2022-04-01T12:21:25","date_gmt":"2022-04-01T16:21:25","guid":{"rendered":"http:\/\/haidut.me\/?p=1808"},"modified":"2022-04-01T12:21:25","modified_gmt":"2022-04-01T16:21:25","slug":"vitamin-a-is-required-for-male-fertility","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1808","title":{"rendered":"Vitamin A is required for male fertility"},"content":{"rendered":"<p>I am posting about this study not because I am thrilled at the possibility of society now having oral (non-steroid) contraceptive methods for males, but rather because this study highlights that vitamin A is actually required for male fertility. Even minor interference with so-called retinoic acid receptor alpha (RAR-a) causes fertility problems and fully blocking that receptor invariably renders all subjects fully infertile. That receptor is activated by all-trans-retinoic acid &#8211; i.e. the &#8220;active&#8221; form of vitamin A synthesized from retinol and its various dietary\/supplement precursors such as retinyl palmitate and retinyl acetate. The study managed to achieve full infertility in 99% of the study subjects (animals) by administering an RAR-a antagonist. The study also claims the effects were reversible after a few months of not using the RAR-a antagonist, but I have serious doubts about that claim. Why? Well, one reason is that vitamin A deficiency has been shown in many animal studies to often cause irreversible sterility if maintained for a sufficiently long period of time. The study itself readily acknowledges that fact while also explicitly stating that the RAR-a antagonist was initially abandoned by the pharma company that discovered it, since it was confirmed it acted as a &#8220;testicular toxin&#8221;. Also, considering vitamin A is a required factor for steroidogenesis, and not just spermatogenesis, interfering with the RAR-a receptor may lead to hypogonadism severe enough to cause testicular atrophy, which is rarely reversible. Finally, since vitamin A and RAR-a activation are required for proper vision, this study may end up unleashing on the world a &#8220;solution&#8221; that causes terrible health problems in males on a global scale. Hhhm, if I was an evil person, dedicated to the cause of depopulation, I would probably think this drug is a &#8220;gift&#8221; from the gods. I wonder who funded those studies&#8230;Yes, that right, CONRAD &#8211; funded by Bill Gates and many other &#8220;elites&#8221; with an openly stated depopulation agenda.<\/p>\n<p>So, all in all, this study below should serve as a serious warning to the crowd out there arguing that supplementing with ANY amount of vitamin A is &#8220;toxic&#8221; and that apparently many health problems can be &#8220;cured&#8221; by simply restricting vitamin A in take to the point of deficiency. Considering fertility is one of the primary biomarkers of good systemic health in males (and in females too), I fail to see how degrading it by reducing the activation of RAR-a (through vitamin A intake restriction) is in any way healthy. Perhaps the multitude of studies demonstrating virtually guaranteed cancer (usually hematological) development in organisms deficient in vitamin A would be even more convincing&#8230;if the vitamin A haters can even be bothered reading them.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1210\/en.2010-0941\">http:\/\/dx.doi.org\/10.1210\/en.2010-0941<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedaily.com\/releases\/2011\/06\/110604181844.htm\">https:\/\/www.sciencedaily.com\/releases\/2011\/06\/110604181844.htm<\/a><\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline;\"><strong>Scientists have known for almost 100 years that depriving an animal of dietary vitamin A causes male <span style=\"color: #ff0000; text-decoration: underline;\">sterility<\/span><\/strong><\/span>. While investigating targeted loss of function of the gene encoding one of the RARs, <span style=\"text-decoration: underline;\"><strong>RARalpha<\/strong><\/span>, which results in male infertility, senior author Debra J. Wolgemuth, Ph.D., ran across a paper by Bristol-Myers Squibb on a compound that was being tested for the treatment of skin and inflammatory diseases. <span style=\"text-decoration: underline; color: #ff0000;\"><strong>The compound seemed to cause changes in the testis<\/strong><\/span> similar to the mutation that she and Dr. Chung were studying in Dr. Wolgemuth&#8217;s lab. (Dr. Wolgemuth is professor of genetics and development and of obstetrics and gynecology; and Dr. Chung is an associate research scientist, both at Columbia University Medical Center). <span style=\"text-decoration: underline;\"><strong>Bristol-Myers dropped its interest when it found that the compound also was \u00ac- in the company&#8217;s words &#8212; &#8220;<span style=\"color: #ff0000; text-decoration: underline;\">a testicular toxin<\/span>.&#8221;<\/strong><\/span> The paper did not elaborate on how the drug caused infertility, so Dr. Wolgemuth and her team tested the drug in mice to find out; they noted that the changes it caused were similar to what one sees with vitamin A-deficiency and loss of function of RARalpha. &#8220;We were intrigued,&#8221; said Dr. Wolgemuth. &#8220;<span style=\"text-decoration: underline;\"><strong>One company&#8217;s toxin may be another person&#8217;s contraceptive<\/strong><\/span>.&#8221; To investigate whether the compound prevented conception at even lower levels than those cited in the company&#8217;s study, Dr. Wolgemuth and her team placed the treated male mice with females and found that <span style=\"text-decoration: underline;\"><strong>reversible male sterility occurred with doses as low as 1.0mg\/kg of body weight for a 4-week dosing period<\/strong><\/span>. One advantage of using a non-steroidal approach, the researchers say, is avoiding the side effects commonly associated with steroidal hormone-based methods.&#8221;<\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline;\"><strong>This study was supported in part by grants initially from CONRAD<\/strong><\/span> and subsequently from the NIH, NICHD.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I am posting about this study not because I am thrilled at the possibility of society now&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[15,87,88,1694,1695,1611,1609],"class_list":["post-1808","post","type-post","status-publish","format-standard","hentry","category-science","tag-antagonist","tag-fertility","tag-male","tag-retinoic-acid","tag-retinoic-acid-receptor","tag-retinol","tag-vitamin-a","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1808"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1808\/revisions"}],"predecessor-version":[{"id":1809,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1808\/revisions\/1809"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}