{"id":1766,"date":"2022-03-30T12:54:54","date_gmt":"2022-03-30T16:54:54","guid":{"rendered":"http:\/\/haidut.me\/?p=1766"},"modified":"2022-03-30T12:54:54","modified_gmt":"2022-03-30T16:54:54","slug":"endotoxin-lps-drives-obesity-diabetes-and-cvd-in-young-people","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1766","title":{"rendered":"Endotoxin (LPS) drives obesity, diabetes and CVD in young people"},"content":{"rendered":"<p>It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal factor in a number of chronic conditions in adults, including diseases not considered to be metabolic such as Alzheimer&#8217;s Disease (AD), Parkinson Disease (PD), scleroderma, cancer, etc. Now, the study below implicates LPS as a causal factor in the whole spectrum of &#8220;metabolic&#8221; diseases in young people, including obesity, metabolic syndrome, diabetes II, liver disease (NAFLD), and cardiovascular disease (CVD). It looks like simple blood tests for unbnound\/free endotoxin (LPS), the LPS binding protein, and an immunoglobulin rising when LPS levels are high, is a sufficient battery of tests to determine LPS status of a person. The first two of those tests seem to be fairly routine and can probably be ordered easily by most GP doctors, and are probably offerred a-la-carte by many &#8220;self-test&#8221; companies too, so it be worth adding those to the lists of tests to do on the annual checkup most people undergo.<\/p>\n<p><a href=\"https:\/\/academic.oup.com\/jcem\/advance-article-abstract\/doi\/10.1210\/clinem\/dgac149\/6547256?login=false\">https:\/\/academic.oup.com\/jcem\/advance-article-abstract\/doi\/10.1210\/clinem\/dgac149\/6547256?login=false<\/a><\/p>\n<p><a href=\"https:\/\/medicaldialogues.in\/diabetes-endocrinology\/news\/endotoxin-biomarkers-associated-with-obesity-and-cardiometabolic-risk-in-youth-study-reveals-90599\">https:\/\/medicaldialogues.in\/diabetes-endocrinology\/news\/endotoxin-biomarkers-associated-with-obesity-and-cardiometabolic-risk-in-youth-study-reveals-90599<\/a><\/p>\n<p>&#8220;&#8230;<span style=\"text-decoration: underline;\"><strong>Metabolic endotoxemia is shown to be a shared mechanism underlying childhood obesity and early-onset metabolic diseases (e.g., non-alcoholic fatty liver disease, type 2 diabetes)<\/strong><\/span>. Against this context, Wei Perng, Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA, and colleagues aimed to examine prospective <span style=\"text-decoration: underline;\"><strong>associations of serum endotoxin biomarkers lipopolysaccharide (LPS) and its binding protein, LPS binding protein (LBP), and anti-endotoxin core IgG (EndoCabIgG) with adiposity and cardiometabolic risk in youth<\/strong><\/span> in a prospective study.&#8221;<\/p>\n<p>&#8220;&#8230;The researchers reported the following findings:<\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\"><strong>Higher LPS and LBP predicted greater adiposity across follow-up<\/strong><\/span>.<\/li>\n<li><strong><span style=\"text-decoration: underline;\">Each 1-unit ln-transformed LPS corresponded with 0.23 units BMI z-score, 5.66 mm<\/span> <sup>3<\/sup> VAT, 30.7 mm <sup>3<\/sup> SAT, and 8.26 mm skinfold sum<\/strong>. EndoCabIgG was associated with VAT only (3.03 mm <sup>3<\/sup>).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>LPS was associated with higher insulin (1.93 \u00b5U\/mL) and leptin (2.28 ng\/mL), and an adverse lipid profile<\/strong><\/span>.<\/li>\n<li>No association was observed with HFF. Accounting for pubertal status and lifestyle behaviors did not change findings.<\/li>\n<li>Adjustment for pre-pregnancy BMI and gestational diabetes attenuated most associations.<\/li>\n<\/ul>\n<p>&#8230;&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[166,285,9,10,59,319,11,66],"class_list":["post-1766","post","type-post","status-publish","format-standard","hentry","category-science","tag-cvd","tag-diabetes","tag-endotoxin","tag-lps","tag-nafld","tag-obesity","tag-tlr4","tag-young","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1766","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1766"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1766\/revisions"}],"predecessor-version":[{"id":1767,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1766\/revisions\/1767"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1766"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1766"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}