Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably increase the production of reactive oxygen species (ROS), which is known to lead to lipid peroxidation, hypercoagulation, and eventually cytokine storm in the most energetically compromised patients. As the study authors state, this explains why certain people with chronic conditions are at increased risk of severe COVID-19 or death – i.e. they are already in an energetically compromised state and COVID-19 greatly exacerbates the existing energetic deficiency. This suggests that chemicals like methylene blue (MB), which can bypass (and often rectify) complex I issues may be a viable treatment (and possibly prevention as well) for COVID-19, especially in already energetically compromised patients. MB has already been shown to be able to directly kill the virus, which makes it that much more appropriate as a therapeutic intervention. Unfortunately, the ongoing human clinical trials with MB for COVID-19 use very high doses (100mg several times daily), which increase the risk of elevating serotonin and the latter is already known to be a major risk factor for COVID-19 exacerbation and\/or subsequent death. Considering most human trials with MB found no benefit beyond 15mg daily (even for a severe disease such as Alzheimer’s), I think a much more sensible approach would be to take say 5mg and spend a few hours in the sun, thus implementing the so-called photodynamic therapy, which Pfizer recently patented as a viable treatment for cancer.<\/p>\n
https:\/\/doi.org\/10.1038\/s41598-020-79552-z<\/a><\/p>\n New Discovery Helps Explain How COVID-19 Overpowers the Immune System<\/a><\/p><\/blockquote>\n