{"id":1531,"date":"2021-05-30T16:45:38","date_gmt":"2021-05-30T20:45:38","guid":{"rendered":"http:\/\/haidut.me\/?p=1531"},"modified":"2021-05-30T16:45:38","modified_gmt":"2021-05-30T20:45:38","slug":"mitochondrial-dysfunction-may-be-the-cause-of-anemia","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1531","title":{"rendered":"Mitochondrial dysfunction may be the cause of anemia"},"content":{"rendered":"<p>Despite anemia being a pretty common condition, I still don&#8217;t think medicine has a good idea what causes anemia (putting aside the more obvious reasons such as chronic bleeding and dietary iron deficiency). In one of the KMUD interviews Peat opined that in his opinion true\u00a0 iron deficiency anemias were rare and the anemias characterized by low hemoglobin, low ferritin, low iron saturation index, etc. were instead tied to poor thyroid function (i.e. energetic deficiency). The study below corroborates that view by discovering that CoQ10 deficiency, a vital co-factor for proper functioning of the electron transport chain (ETC), reliably causes anemia and replenishing CoQ10 stores quickly reversed the anemia. This is further corroborated by various anecdotal reports and published case studies demonstrating that vitamin K (another electron-carrier-capable molecule similar to, but more effective than, CoQ10) is also effective as anemia treatment. Thus, once again we have a condition often diagnosed by doctors as idiopathic turn out to be nothing more but energetic deficiency in disguise.<\/p>\n<p><a href=\"https:\/\/science.sciencemag.org\/content\/372\/6543\/716\">https:\/\/science.sciencemag.org\/content\/372\/6543\/716<\/a><\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"I3Yjh9FkL9\"><p><a href=\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/05\/new-connection-between-metabolism-and-red-blood-cell-development\/\">Not so black and white<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Not so black and white&#8221; &#8212; Harvard Gazette\" src=\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/05\/new-connection-between-metabolism-and-red-blood-cell-development\/embed\/#?secret=V3OpeXcbjt#?secret=I3Yjh9FkL9\" data-secret=\"I3Yjh9FkL9\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>&#8220;&#8230;\u201cMetabolic programs are hardwired in every single tissue and the pathways are really similar to each other. But it turns out that because of the unique demands of the tissues, there are certain control mechanisms that each tissue uses to fine tune its metabolic pathways,\u201d said senior author Leonard Zon, who is a professor of stem cell and regenerative biology and the Grousbeck Professor of Pediatrics at Harvard. \u201cIn this particular study, we uncovered a very important mechanism by which <span style=\"text-decoration: underline;\"><strong>red blood cell precursors regulate their metabolism, by having a dedicated transcription factor to drive the production of the metabolite coenzyme Q<\/strong><\/span>.\u201d<\/p>\n<p>&#8220;&#8230;\u201c<span style=\"text-decoration: underline;\"><strong>This enzyme sits right inside mitochondria, leading us to speculate that in our case it actually has less to do with nucleotide biosynthesis than with mitochondrial functions<\/strong><\/span>. That\u2019s what brought us to investigate mitochondrial metabolism,\u201d Rossmann said. The researchers found that TIF1\u03b3 directly controls <span style=\"text-decoration: underline;\"><strong>many of the enzymes that are involved in the production of coenzyme Q, an important part of the energy-producing respiratory chain in mitochondria. The researchers confirmed that <span style=\"color: #ff0000; text-decoration: underline;\">the zebrafish anemia model had low levels of coenzyme Q, and that adding back an analog of coenzyme Q rescued the blood production defect<\/span><\/strong><\/span>.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despite anemia being a pretty common condition, I still don&#8217;t think medicine has a good idea what&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[1541,1455,98,1543,77,1542,443],"class_list":["post-1531","post","type-post","status-publish","format-standard","hentry","category-science","tag-anemia","tag-coq10","tag-energy","tag-epo","tag-mitochondria","tag-rbc","tag-vitamin-k","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1531"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1531\/revisions"}],"predecessor-version":[{"id":1532,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1531\/revisions\/1532"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}