A study that once again illustrates the central principle of bioenergetics – structure and function cannot be separated. They are interdependent at every level. In this specific case, the “structural” pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when evaluating such condition, will look for structural problems such as genetic mutations, trauma, fibrosis, tumors, etc that may lead to this condition. If none such causes are found then the disorder will be declared “functional” and treated “supportively” by managing the symptoms so that the “quality of life” of the patient is maintained as much as possible. In other words, medicine would give up on trying to cure the condition because the issue is not “structural”. Well, the study below demonstrates that this structural condition has a very functional origin. Namely, poor mitochondrial function, which led to decreases ATP levels and CO2 production, and decreased levels of mDNA synthesis (a hallmark of mitochondrial pathology). As such, it suggests that most such muscle wasting conditions may (and should?) be treated by simply improving the energetic flow through dietary and supplement interventions. Increased glucose, saturated fats (as they stimulate mitochondrial biogenesis), niacinamide, thiamine, methylene blue, CoQ10, progesterone, DHEA, T\/DHT, etc.<\/p>\n
https:\/\/skeletalmusclejournal.biomedcentral.com\/articles\/10.1186\/s13395-021-00263-8<\/a><\/p>\n Muscle Weakness Tied to Poor Mitochondria Function<\/a><\/p><\/blockquote>\n