{"id":1497,"date":"2021-04-27T15:43:17","date_gmt":"2021-04-27T19:43:17","guid":{"rendered":"http:\/\/haidut.me\/?p=1497"},"modified":"2021-04-27T15:43:17","modified_gmt":"2021-04-27T19:43:17","slug":"low-dht-can-cause-hypogonadism-symptoms-even-in-eugonadal-men","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1497","title":{"rendered":"Low DHT can cause hypogonadism symptoms even in eugonadal men"},"content":{"rendered":"

Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and “aging male” syndrome. For every 10% increase in DHT levels there was a 4.67% decrease in hypogonadism symptoms of eugonadal males. So, once again, this is evidence that testosterone (T) is little more than a pro-hormone produced in the gonads and peripheral tissues and that its metabolite DHT is the primary androgen responsible for health of males.<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/33811609\/<\/a><\/p>\n

“…Results:\u00a0<\/strong>Serum total\/free T as well as dihydro-T (DHT) was associated with IIEF-EF and AMS scores in the overall population using univariate analyses. Multivariate approaches revealed DHT concentrations in subjects with normal T levels (n = 416, Total T > 12 nmol\/L) to be significant predictors of AMS scores. A 0.1 nmol\/l serum DHT increase within the eugonadal range was associated with a 4.67% decrease in odds of having worse symptoms<\/strong><\/span> (p = 0.011). In men with biochemical hypogonadism (Total T < 12 nmol\/L), total and free T rather than DHT were associated with AMS results. This association was not found for IIEF-EF scores. Indirect effects of age and BMI were seen for relations with hormone concentrations but not questionnaire scores. Conclusion:\u00a0<\/strong>DHT can be associated with symptoms of hypogonadism in biochemically eugonadal men<\/strong><\/span>. Serum DHT measurement might be helpful once the diagnosis of hypogonadism has been ruled out but should not be routinely included in the primary diagnostic process.”<\/p>\n","protected":false},"excerpt":{"rendered":"

Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[101,661,659,742,1517,231,1518],"class_list":["post-1497","post","type-post","status-publish","format-standard","hentry","category-science","tag-aging","tag-androgen","tag-dht","tag-erectile-dysfunction","tag-eugonadal","tag-hypogonadism","tag-sexual-dysfunction","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1497"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1497\/revisions"}],"predecessor-version":[{"id":1498,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1497\/revisions\/1498"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}