{"id":1489,"date":"2021-04-27T14:32:12","date_gmt":"2021-04-27T18:32:12","guid":{"rendered":"http:\/\/haidut.me\/?p=1489"},"modified":"2021-04-27T14:32:12","modified_gmt":"2021-04-27T18:32:12","slug":"vitamin-d-topical-safe-and-effective-for-removing-scars","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1489","title":{"rendered":"Vitamin D (topical) safe and effective for removing scars"},"content":{"rendered":"

A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical\/heat burns, radiation, etc. As the study says, the typical treatment is with cortisol injections, however the effectiveness is less than 10%, and the only other option is cosmetic surgery, which of course leaves scars of its own and can hardly be considered a “solution”. Humble vitamin D may come to the rescue and even though the study used injections of the vitamin into the scar, topical administration of vitamin D has also been found to achieve high skin concentrations. The dosage used in the study was 200,000 of vitamin D3, and all that was needed was 3-4 sessions of such treatment. The mechanism of action, as expected, was the antifibrotic effects of vitamin D, which I have discussed many times in my posts. The study abstract does not mention timing\/duration but considering mos doctors prescribe 50,000 IU weekly, this suggests the study used the 200,000 IU once monthly and as such the treatment duration was 3-4 months. There is no reason why the same effects cannot be achieved with daily treatments using lower doses, which means daily topical administration of 10,000 IU – 15,000 IU of vitamin D3 (higher dose than the 200,000 \/ 30 in order to account for absorption of less than 100% through the skin) should be able to achieve similar results.<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/33721390\/<\/a><\/p>\n

https:\/\/www.dermatologytimes.com\/view\/the-role-of-vitamin-d-in-keloid-scar-treatment<\/a><\/p>\n

“…A recent study in the Journal of Cosmetic Dermatology examines the safety and efficacy of using vitamin D intralesional injection for the treatment of keloid scars<\/strong><\/span>. Treating keloid scars continue to be a particular challenge for dermatologists due to the scars oversized nature, continued growth, and difficult treatment. While intralesional corticosteroid injection is considered first-line treatment for keloids<\/strong><\/span>, a recent study in the Journal of Cosmetic Dermatology1 (JCD) examined vitamin D efficacy treating keloids using intralesional injection. Vitamin D slows the progression of tissue fibrosis by keloid fibroblasts and inhibits collagen synthesis in dermal fibrosis<\/strong><\/span>, according to the study, making the vitamin a key player in cell proliferation and differentiation. The study, which evaluated the efficacy of intralesional injection of vitamin D in the treatment of keloids, both clinically and ultrasonically, included 40 patients with keloids. Patients were injected weekly with intralesional vitamin D at a dose of 0.2 ml (200,000 IU) per 1 cm lesion<\/strong><\/span>. The keloid scars were evaluated before and after treatment with the Vancouver Scar Scale (VSS) and by a high-resolution ultrasound using B mode. Study patients received 3 to 4 sessions.<\/span> Results showed a statistically significant reduction in VSS after treatment with the vitamin injection (p value \u22640.001) along with a highly significant improvement in ultrasonic keloid scar thickness post-treatment<\/strong> (P value \u22640.001). From this data, study investigators concluded that intralesional vitamin D is a safe and effective treatment of keloid scares<\/strong><\/span>. Additionally, ultrasound is useful in assessing keloid improvement after treatment.”<\/p>\n","protected":false},"excerpt":{"rendered":"

A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[50,64,1510,1511,221,49,162],"class_list":["post-1489","post","type-post","status-publish","format-standard","hentry","category-science","tag-cholecalciferol","tag-fibrosis","tag-keloid","tag-scars","tag-skin","tag-vitamin-d","tag-vitamin-d3","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1489"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1489\/revisions"}],"predecessor-version":[{"id":1490,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1489\/revisions\/1490"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}