{"id":1462,"date":"2021-03-17T14:04:36","date_gmt":"2021-03-17T18:04:36","guid":{"rendered":"http:\/\/haidut.me\/?p=1462"},"modified":"2021-03-17T14:04:36","modified_gmt":"2021-03-17T18:04:36","slug":"replacing-starch-with-sucrose-increases-metabolism-prevent-obesity","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1462","title":{"rendered":"Replacing starch with sucrose increases metabolism, prevent obesity"},"content":{"rendered":"<p>A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to dispute. Namely, feeding a diet for 15 weeks, in which 74.3% of the calories come from carbs in the form of starch was clearly obesogenic, caused insulin resistance and elevated blood glucose, triglycerides, and free fatty acids (FFA). Replacing 38.5% of the calories with sucrose resulted in striking insulin sensitivity, lower triglycerides, and lower free fatty acids in the blood <span style=\"text-decoration: underline;\"><strong>despite the highest caloric daily intake in the high-sucrose group<\/strong><\/span> compared to both the normal and high-starch diet groups. And the mechanism behind these highly beneficial effects of sucrose? Increase in the resting metabolic rate by about 20%. So much for the &#8220;white poison&#8221; rearing its ugly head in every grocery store. \ud83d\ude42<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28886439\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28886439\/<\/a><\/p>\n<p>&#8220;&#8230;In this study, we show that <strong>mice fed a chronic\u00a0<a title=\"Learn more about High-Sucrose Diet from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/high-sucrose-diet\">high-sucrose diet<\/a>\u00a0do not develop obesity, primarily due to an increase of energy expenditure<\/strong> <strong>accompanied with increased expression levels of ChREBP and\u00a0<a title=\"Learn more about FGF21 from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fgf21\">FGF21<\/a>\u00a0mRNA in liver and BAT<\/strong>. Body weight as well as\u00a0<a title=\"Learn more about Glucose Metabolism from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glucose-metabolism\">glucose metabolism<\/a>\u00a0is regulated by various hormones such as\u00a0<a title=\"Learn more about Glucagon Like Peptide 1 from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glucagon-like-peptide-1\">GLP-1<\/a>, which contributes to reduction of weight gain by slowing gastric emptying and suppressing appetite\u00a0<a class=\"workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286317301948?via%3Dihub#bb0040\" name=\"bbb0040\">[8]<\/a>\u00a0as well as increasing energy expenditure\u00a0<a class=\"workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286317301948?via%3Dihub#bb0050\" name=\"bbb0050\">[10]<\/a>,\u00a0<a class=\"workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286317301948?via%3Dihub#bb0055\" name=\"bbb0055\">[11]<\/a>.&#8221;<\/p>\n<p>&#8220;&#8230;Thus, chronic high-sucrose diet increases FGF21 production concomitant with increase of the expression levels of ChREBP mRNA in liver and BAT. It also increases the expression levels of FGFR1c and KLB mRNA. <strong>These changes act to attenuate weight gain by increasing energy expenditure<\/strong> (<a class=\"workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286317301948?via%3Dihub#f0030\" name=\"bf0030\">Fig. 6<\/a>)&#8230;<span style=\"color: #ff0000;\"><strong>SUC-fed mice show increased energy expenditure and potent insulin sensitivity<\/strong><\/span>&#8230;&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[489,283,334,1199,284,319,1005,1497],"class_list":["post-1462","post","type-post","status-publish","format-standard","hentry","category-science","tag-blood-glucose","tag-ffa","tag-insulin","tag-metabolic-rate","tag-nefa","tag-obesity","tag-sucrose","tag-trigylcerides","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1462"}],"version-history":[{"count":1,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1462\/revisions"}],"predecessor-version":[{"id":1463,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1462\/revisions\/1463"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}