Danny and I already discussed this topic on a recent podcast, but I decided to post the studies anyways, considering how important the topic is. While progesterone and testosterone are the most well-known differentiating factors in humans, the role of vitamin D has gone largely unnoticed. The studies below demonstrate that vitamin D is a powerful differentiating agent, and can cause the regression of even advanced tumors when used in doses proven to be safe for most people (5,000 IU – 10,000 IU daily). The studies cover both in-vitro and in-vivo models and the third link is a human case report. Importantly, at least two of the studies (second and third to last) demonstrate that the “inactive” cholecalciferol (25-OH-D3, commonly used as a supplement) is just as active in terms of differentiating effects as the “active” form known as 1,25-OH-D3 (calcitriol). Moreover, cholecalciferol has a much lower risk of causing hypercalcemia compared to calcitriol, and in fact may lower elevated levels of calcitriol that are seen in many chronic inflammatory conditions.<\/p>\n
https:\/\/pubmed.ncbi.nlm.nih.gov\/8286848\/<\/a><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/8384998\/<\/a><\/p>\n https:\/\/www.longdom.org\/open-access\/longterm-remission-of-adenoid-cystic-tongue-carcinoma-with-low-dose-naltrexone-and-vitamin-d-a-case-report-2247-2452.1000662.pdf<\/a><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/8202625\/<\/a><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/32069830\/<\/a><\/p>\n https:\/\/www.discoverymedicine.com\/Julian-L-Ambrus\/2009\/07\/26\/attempts-to-induce-differentiation-of-neoplastic-cells-to-normal\/<\/a><\/p>\n “…Several investigators reported that 1,25-dihydroxyvitamin D3<\/sup><\/sub>\u00a0(vD3<\/sup><\/sub>) and its active metabolite cholecalciferol<\/span> (calcitriol, DHCC) causes monocytic differentiation of leukemia cells<\/span><\/strong>. This appears to be due in part to down-regulation of expression of cell cycle related proto-oncogenes (e.g., c-myc). Differentiation inducing effect was also seen against certain solid tumors including prostatic cancer and squamous cell carcinoma<\/strong>.”<\/p>\n “…In a number of studies, vD3<\/sup><\/sub><\/strong>\u00a0was evaluated as a growth inhibitor. In tissue culture studies it was found effective in\u00a0osteosarcoma<\/a>, squamous cell carcinoma,\u00a0breast cancer<\/a>,\u00a0prostate cancer<\/a>, and leukemias<\/strong>.”<\/p>\n