{"id":1031,"date":"2020-04-21T23:27:06","date_gmt":"2020-04-22T03:27:06","guid":{"rendered":"http:\/\/haidut.me\/?p=1031"},"modified":"2020-04-21T23:28:20","modified_gmt":"2020-04-22T03:28:20","slug":"alzheimer-disease-ad-linked-to-pufa-accumulation-in-brain","status":"publish","type":"post","link":"https:\/\/haidut.me\/?p=1031","title":{"rendered":"Alzheimer Disease (AD) linked to PUFA accumulation in brain"},"content":{"rendered":"<p>So much for the &#8220;beneficial&#8221; effects of PUFA. What makes this study particularly interesting is that it calls into question a favorite defensive maneuver of clinical nutritionists. Namely, when challenged about the known inflammatory effects of omega-6 fatty acids, most medical professionals make a desperate claim that omega-3 fatty acids are actually protective and we should try to increase the omega-3\/omega-6 ratio instead of criticizing all PUFA. Well, the study below pours cold water on that claim as it found that AD is associated with a build up of <span style=\"text-decoration: underline;\"><strong>all<\/strong><\/span> major PUFA, both omega-6 and omega-3, as well as one of the MUFA. So, those fish oil supplements we still see advertised on TV are likely worse than useless &#8211; they may directly cause AD if used for a sufficiently long period of time. In contrast, not a single saturated fatty acid was found to be associated with AD, and I think that by itself speaks volumes of who the culprit is. Perhaps just as importantly, in the lead author&#8217;s own words, the study corroborates once again the hypothesis that AD is a metabolic condition.<\/p>\n<p><a href=\"https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.1002266\">https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.1002266<\/a><\/p>\n<p><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/316500\">https:\/\/www.medicalnewstoday.com\/articles\/316500<\/a><\/p>\n<p>&#8220;&#8230;Researchers are studying <strong>late-onset Alzheimer\u2019s in the context of age-related brain changes. A new study<\/strong> \u2013\u00a0<a class=\"content-link css-29oowu\" href=\"http:\/\/dx.doi.org\/10.1371\/journal.pmed.1002266\" target=\"_blank\" rel=\"noopener noreferrer\">published<\/a>\u00a0in the journal\u00a0<em>PLOS Medicine<\/em> \u2013 <strong>looks at how fatty acid metabolites in the brain tissue of healthy seniors behave and affect the participants\u2019 cognitive abilities<\/strong>.&#8221;<\/p>\n<p>&#8220;&#8230;<strong>The researchers measured the metabolite levels of the brain regions commonly associated with Alzheimer\u2019s<\/strong>: the middle frontal gyrus and the inferior temporal gyrus. They also examined metabolite levels in a brain area that is not normally affected by Alzheimer\u2019s pathology \u2013 the cerebellum&#8230;<span style=\"color: #ff0000;\"><strong>The fatty acids shown to correlate with AD in this study were: docosahexaenoic acid, linoleic acid, arachidonic acid, linolenic acid, eicosapentaenoic acid, and oleic acid<\/strong><\/span>. Cristina Legido-Quigley and colleagues explain the significance of the study: \u201c<strong>[This] work suggests that dysregulation of UFA\u2019s metabolism plays a role in driving AD pathology and that these results provide <span style=\"color: #ff0000;\">further evidence for the metabolic basis of AD<\/span> pathogenesis<\/strong>.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>So much for the &#8220;beneficial&#8221; effects of PUFA. What makes this study particularly interesting is that it&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[1220,729,730,138,33,1043,1042,159],"class_list":["post-1031","post","type-post","status-publish","format-standard","hentry","category-science","tag-accumulate","tag-alzheimer","tag-alzheimer-disease","tag-brain","tag-cause","tag-omega-3","tag-omega-6","tag-pufa","wpcat-2-id"],"_links":{"self":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1031"}],"version-history":[{"count":3,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1031\/revisions"}],"predecessor-version":[{"id":1034,"href":"https:\/\/haidut.me\/index.php?rest_route=\/wp\/v2\/posts\/1031\/revisions\/1034"}],"wp:attachment":[{"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haidut.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}